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https://doi.org/10.2478/acph-2022-0009

Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats

BOJANA DIMITROVA ; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia
RUMYANA VITANSKA ; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia
RENETA GEVRENOVA ; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia
DIMITRINA ZHELEVA-DIMITROVA ; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia
VESSELA BALABANOVA ; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia
STOYCHO STOEV ; Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria

Puni tekst: engleski, pdf (4 MB) str. 59-77 preuzimanja: 45* citiraj
APA 6th Edition
DIMITROVA, B., VITANSKA, R., GEVRENOVA, R., ZHELEVA-DIMITROVA, D., BALABANOVA, V. i STOEV, S. (2022). Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats. Acta Pharmaceutica, 72 (1), 59-77. https://doi.org/10.2478/acph-2022-0009
MLA 8th Edition
DIMITROVA, BOJANA, et al. "Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats." Acta Pharmaceutica, vol. 72, br. 1, 2022, str. 59-77. https://doi.org/10.2478/acph-2022-0009. Citirano 28.10.2021.
Chicago 17th Edition
DIMITROVA, BOJANA, RUMYANA VITANSKA, RENETA GEVRENOVA, DIMITRINA ZHELEVA-DIMITROVA, VESSELA BALABANOVA i STOYCHO STOEV. "Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats." Acta Pharmaceutica 72, br. 1 (2022): 59-77. https://doi.org/10.2478/acph-2022-0009
Harvard
DIMITROVA, B., et al. (2022). 'Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats', Acta Pharmaceutica, 72(1), str. 59-77. https://doi.org/10.2478/acph-2022-0009
Vancouver
DIMITROVA B, VITANSKA R, GEVRENOVA R, ZHELEVA-DIMITROVA D, BALABANOVA V, STOEV S. Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats. Acta Pharm. [Internet]. 2022 [pristupljeno 28.10.2021.];72(1):59-77. https://doi.org/10.2478/acph-2022-0009
IEEE
B. DIMITROVA, R. VITANSKA, R. GEVRENOVA, D. ZHELEVA-DIMITROVA, V. BALABANOVA i S. STOEV, "Molecular networking-assisted flavonoid profile of Gypsophila glomerata extract in relation to its protective effects on carbon tetrachloride-induced hepatorenal damage in rats", Acta Pharmaceutica, vol.72, br. 1, str. 59-77, 2022. [Online]. https://doi.org/10.2478/acph-2022-0009

Sažetak
The aim of the study was to provide an in-depth characterization of the methanol-aqueous extract from the aerial parts of Gypsophila glomerata Pall. Ex Adams (Caryophyllaceae) (EGG) and to assess its protective potential on carbon tetrachloride (CCl4)-induced liver and kidney damage in male Wistar rats. Twenty-two flavonoid C-, O- and C,O-glycosides in EGG were annotated by mass spectrometry-based molecular networking; nine of them are reported in this species for the first time. Fourteen-day oral administration of EGG at a dose 200 mg kg–1 bm prevented significantly CCl4-induced liver injury, discerned by an amelioration of the markers of oxidative stress (GSH and MDA) and transaminase activity. EGG decreased the serum level of urea and creatinine as well. The observed improvement of biochemical parameters was supported by histopathological observations. The protective hepatorenal effects of EGG, rich in 2"-О-pentosyl-6-С-hexosyl-apigenin/luteolin/methylluteolin and their acetyl- and methoxycinnamoyl-derivatives, were comparable with the effects of the positive control silymarin.

Ključne riječi
Gypsophila glomerata; CCl4; molecular network; hepatorenal toxicity; flavonoids

Hrčak ID: 253983

URI
https://hrcak.srce.hr/253983

Posjeta: 87 *