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https://doi.org/10.18054/pb.v121-122i1-2.10603

Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review

Renata Odžak   ORCID icon orcid.org/0000-0002-2325-464X ; University of Split, Faculty of Science
Matilda Šprung ; University of Split, Faculty of Science

Puni tekst: engleski, pdf (420 KB) str. 15-21 preuzimanja: 49* citiraj
APA 6th Edition
Odžak, R. i Šprung, M. (2020). Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review. Periodicum biologorum, 121-122 (1-2), 15-21. https://doi.org/10.18054/pb.v121-122i1-2.10603
MLA 8th Edition
Odžak, Renata i Matilda Šprung. "Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review." Periodicum biologorum, vol. 121-122, br. 1-2, 2020, str. 15-21. https://doi.org/10.18054/pb.v121-122i1-2.10603. Citirano 16.05.2021.
Chicago 17th Edition
Odžak, Renata i Matilda Šprung. "Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review." Periodicum biologorum 121-122, br. 1-2 (2020): 15-21. https://doi.org/10.18054/pb.v121-122i1-2.10603
Harvard
Odžak, R., i Šprung, M. (2020). 'Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review', Periodicum biologorum, 121-122(1-2), str. 15-21. https://doi.org/10.18054/pb.v121-122i1-2.10603
Vancouver
Odžak R, Šprung M. Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review. Periodicum biologorum [Internet]. 2020 [pristupljeno 16.05.2021.];121-122(1-2):15-21. https://doi.org/10.18054/pb.v121-122i1-2.10603
IEEE
R. Odžak i M. Šprung, "Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review", Periodicum biologorum, vol.121-122, br. 1-2, str. 15-21, 2020. [Online]. https://doi.org/10.18054/pb.v121-122i1-2.10603

Sažetak

Quaternary ammonium compounds (QACs) have a long-known application as antiseptics and disinfectants applied in various industries such as pharmaceutical, agricultural and food industry. Given the alarming number of QACs resistant bacteria, there is an urgent need to develop new QACs with broad-spectrum antimicrobial activities and low tendency to trigger bacterial resistance. One recently proposed approach to develop new QACs is based on quaternization of natural products, which proved to be successful. Quinuclidine is an interesting natural precursor find to be a part of the structure of biologically active cinchona alkaloids. In addition to the well-established medicinal and pharmaceutical potential of 3-substituted quinuclidines, QACs based on 3-substituted quinuclidines, have only recently been shown to exhibit a significant antimicrobial activity. Most importantly, these compounds exhibit low toxicity toward normal human cell lines, which opens up a new chapter in the QACs field ensuring further investigation of possible therapeutic application of 3-substituted quinuclidine based QACs.

Hrčak ID: 254645

URI
https://hrcak.srce.hr/254645

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