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Pregledni rad
https://doi.org/10.26332/seemedj.v5i1.194

Regulation and Dysregulation of Thrombin Activity

Daria Korolova   ORCID icon orcid.org/0000-0002-1249-3442 ; Palladin Institute of Biochemistry, National academy of Sciences of Ukraine, Kyiv, Ukraine

Puni tekst: engleski, pdf (689 KB) str. 47-64 preuzimanja: 39* citiraj
APA 6th Edition
Korolova, D. (2021). Regulation and Dysregulation of Thrombin Activity. Southeastern European Medical Journal, 5 (1), 47-64. https://doi.org/10.26332/seemedj.v5i1.194
MLA 8th Edition
Korolova, Daria. "Regulation and Dysregulation of Thrombin Activity." Southeastern European Medical Journal, vol. 5, br. 1, 2021, str. 47-64. https://doi.org/10.26332/seemedj.v5i1.194. Citirano 28.10.2021.
Chicago 17th Edition
Korolova, Daria. "Regulation and Dysregulation of Thrombin Activity." Southeastern European Medical Journal 5, br. 1 (2021): 47-64. https://doi.org/10.26332/seemedj.v5i1.194
Harvard
Korolova, D. (2021). 'Regulation and Dysregulation of Thrombin Activity', Southeastern European Medical Journal, 5(1), str. 47-64. https://doi.org/10.26332/seemedj.v5i1.194
Vancouver
Korolova D. Regulation and Dysregulation of Thrombin Activity. Southeastern European Medical Journal [Internet]. 2021 [pristupljeno 28.10.2021.];5(1):47-64. https://doi.org/10.26332/seemedj.v5i1.194
IEEE
D. Korolova, "Regulation and Dysregulation of Thrombin Activity", Southeastern European Medical Journal, vol.5, br. 1, str. 47-64, 2021. [Online]. https://doi.org/10.26332/seemedj.v5i1.194

Sažetak
Thrombin is the enzyme of the haemostasis system that stands at the crossroads between the coagulation cascade and coagulation inhibition by protein C, between plasma coagulation factors and cells involved in haemostasis and between haemostasis and the immune system. Allosteric regulation of thrombin and its interaction with various partners in blood plasma and on the surface of the endothelium and platelets provides a wide variety of thrombin functions. The thrombin activity regulation is multifactorial, so a failure of any part of this system leads to serious consequences. An example of this are thrombotic/bleeding complications during endothelial dysfunction, infections, inflammation and uncontrolled treatment.
This review aims to summarize current knowledge about thrombin structure, functions and regulation. Collected data suggest a crucial role of thrombin in different pathologies accompanied by blood coagulation disorders, in particular diseases causing endothelial dysfunction, such as COVID-19.

Ključne riječi
thrombin; protein C; haemostasis; platelets; endothelium; inflammation; COVID-19

Hrčak ID: 256789

URI
https://hrcak.srce.hr/256789

Posjeta: 88 *