hrcak mascot   Srce   HID

Acta Pharmaceutica, Vol. 58 No. 3, 2008.

Kratko priopćenje
https://doi.org/10.2478/v10007-008-0012-5

Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types

SAJJAN ARYAL ; Quest Pharmaceuticals (P) Ltd. Chhata Pipara, Bara, Nepal
NATAŠA ŠKALKO-BASNET ; The School of Pharmaceutical and Biomedical Sciences, Faculty of Science and Technology, Pokhara University, PO Box 427, Pokhara, Nepal

Puni tekst: engleski, pdf (81 KB) str. 299-308 preuzimanja: 4.216* citiraj
APA 6th Edition
ARYAL, S. i ŠKALKO-BASNET, N. (2008). Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types. Acta Pharmaceutica, 58 (3), 299-308. https://doi.org/10.2478/v10007-008-0012-5
MLA 8th Edition
ARYAL, SAJJAN i NATAŠA ŠKALKO-BASNET. "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types." Acta Pharmaceutica, vol. 58, br. 3, 2008, str. 299-308. https://doi.org/10.2478/v10007-008-0012-5. Citirano 19.02.2019.
Chicago 17th Edition
ARYAL, SAJJAN i NATAŠA ŠKALKO-BASNET. "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types." Acta Pharmaceutica 58, br. 3 (2008): 299-308. https://doi.org/10.2478/v10007-008-0012-5
Harvard
ARYAL, S., i ŠKALKO-BASNET, N. (2008). 'Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types', Acta Pharmaceutica, 58(3), str. 299-308. doi: https://doi.org/10.2478/v10007-008-0012-5
Vancouver
ARYAL S, ŠKALKO-BASNET N. Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types. Acta Pharm. [Internet]. 2008 [pristupljeno 19.02.2019.];58(3):299-308. doi: https://doi.org/10.2478/v10007-008-0012-5
IEEE
S. ARYAL i N. ŠKALKO-BASNET, "Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types", Acta Pharmaceutica, vol.58, br. 3, str. 299-308, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0012-5

Sažetak
Multi-drug tablets of amlodipine besylate and atenolol were prepared as either mono-layer (mixed matrix) or bi-layer tablets containing each drug in a separate layer by using similar excipients and processing. Each tablet batch was packed in strip and blister packs and kept under accelerated temperature and humidity conditions. The stability of two tablet and packaging types was compared by HPLC analysis after 0, 1, 3 and 4.5 months and expressed as the content of intact amlodipine and atenolol.
The content of atenolol did not decline regardless of tablet and packaging type. Amlodipine content in bi-layer tablets decreased to about 95 and 88% when packed in strips and blisters, respectively. When prepared as mono-layer tablets, the content decreased to 72 and 32%, respectively.
The study revealed that the bi-layer tablet formulation was more stable than the mono-layer type. Further, the stability was increased when the tablets were packed in aluminium strips as compared to PVC blisters.

Ključne riječi
amlodipine; atenolol; mono-layer; bi-layer tablet

Hrčak ID: 24510

URI
https://hrcak.srce.hr/24510

[hrvatski]

Posjeta: 4.662 *