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Acta Pharmaceutica, Vol. 58 No. 4, 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0021-4

Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators

DINESH KUMAR ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
ROSALIA CARRON ; Departamento de Fisiología y Farmacología, Facultad d Farmacia, Campus "Miguel de Unamuno" E-37007 Salamanca, Spain
CARMEN DE LA CALLE ; Departamento de Fisiología y Farmacología, Facultad d Farmacia, Campus "Miguel de Unamuno" E-37007 Salamanca, Spain
DHARAM PAUL JINDAL ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
RANJU BANSAL ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India

Puni tekst: engleski, pdf (99 KB) str. 393-405 preuzimanja: 699* citiraj
APA 6th Edition
KUMAR, D., CARRON, R., DE LA CALLE, C., PAUL JINDAL, D. i BANSAL, R. (2008). Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators. Acta Pharmaceutica, 58 (4), 393-405. https://doi.org/10.2478/v10007-008-0021-4
MLA 8th Edition
KUMAR, DINESH, et al. "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 393-405. https://doi.org/10.2478/v10007-008-0021-4. Citirano 22.02.2019.
Chicago 17th Edition
KUMAR, DINESH, ROSALIA CARRON, CARMEN DE LA CALLE, DHARAM PAUL JINDAL i RANJU BANSAL. "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators." Acta Pharmaceutica 58, br. 4 (2008): 393-405. https://doi.org/10.2478/v10007-008-0021-4
Harvard
KUMAR, D., et al. (2008). 'Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators', Acta Pharmaceutica, 58(4), str. 393-405. doi: https://doi.org/10.2478/v10007-008-0021-4
Vancouver
KUMAR D, CARRON R, DE LA CALLE C, PAUL JINDAL D, BANSAL R. Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators. Acta Pharm. [Internet]. 2008 [pristupljeno 22.02.2019.];58(4):393-405. doi: https://doi.org/10.2478/v10007-008-0021-4
IEEE
D. KUMAR, R. CARRON, C. DE LA CALLE, D. PAUL JINDAL i R. BANSAL, "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators", Acta Pharmaceutica, vol.58, br. 4, str. 393-405, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0021-4

Sažetak
The present study describes the synthesis and pharmacological evaluation of 2-substituted-6-(4-acylaminophenyl)-4,5-dihydropyridazin-3(2H)-ones as potent inodilating agents. The synthesis of target compounds 2-4 and 7-11 was acieved by Friedel-Crafts acylation of an appropriate anilide derivative with succinic anhydride or methylsuccinic anhydride and subsequent cyclization of intermediary keto acids with various hydrazine derivatives. The newly synthesized pyridazinone derivatives were evaluated for cardiotonic activity using isolated rat atria and for vasorelaxant activity using descending thoracic aortic rings of Wistar rats precontracted with phenylephrine (106 mol L1). 6-(4-Methanesulfonamidophenyl)-2-phenyl-4,5-dihydropyridazin-3(2H)-one (7) exhibited significant inodilatory properties and showed vasorelaxant activity in a nanomolar range (IC50 = 0.08  0.01 μmol L1).

Ključne riječi
pyridazinones; anilides; hydrazine derivatives; cardiotonic activity; vasodilatory activity

Hrčak ID: 26482

URI
https://hrcak.srce.hr/26482

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Posjeta: 930 *