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Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0023-2

Razvoj i in vitro vrednovanje puferiranog bioadhezivnog vaginalnog gela za miješane vaginalne infekcije

FARHAN JALEES AHMAD ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
MOHD AFTAB ALAM ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ZEENAT IQBAL KHAN ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ROOP KRISHEN KHAR ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
MUSHIR ALI ; Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Puni tekst: engleski, pdf (97 KB) str. 407-419 preuzimanja: 1.109* citiraj
APA 6th Edition
AHMAD, F.J., ALAM, M.A., KHAN, Z.I., KHAR, R.K. i ALI, M. (2008). Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharmaceutica, 58 (4), 407-419. https://doi.org/10.2478/v10007-008-0023-2
MLA 8th Edition
AHMAD, FARHAN JALEES, et al. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 407-419. https://doi.org/10.2478/v10007-008-0023-2. Citirano 18.06.2019.
Chicago 17th Edition
AHMAD, FARHAN JALEES, MOHD AFTAB ALAM, ZEENAT IQBAL KHAN, ROOP KRISHEN KHAR i MUSHIR ALI. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica 58, br. 4 (2008): 407-419. https://doi.org/10.2478/v10007-008-0023-2
Harvard
AHMAD, F.J., et al. (2008). 'Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections', Acta Pharmaceutica, 58(4), str. 407-419. doi: https://doi.org/10.2478/v10007-008-0023-2
Vancouver
AHMAD FJ, ALAM MA, KHAN ZI, KHAR RK, ALI M. Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta Pharm. [Internet]. 2008 [pristupljeno 18.06.2019.];58(4):407-419. doi: https://doi.org/10.2478/v10007-008-0023-2
IEEE
F.J. AHMAD, M.A. ALAM, Z.I. KHAN, R.K. KHAR i M. ALI, "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections", Acta Pharmaceutica, vol.58, br. 4, str. 407-419, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0023-2

Sažetak
U radu je opisan razvoj puferiranog biodhezivnog vaginalnog (acid buffering bioadhesive vaginal, ABBV) gela za terapiju miješanih vaginalnih infekcija. Ispitani su različiti bioadhezivni polimeri  procijenjena su njihova bioadhezivna svojstva, stabilnost i sposobnost oslobađanja ljekovite tvari. Guar guma, ksantan guma i hidroksipropilmetilceluloza K4M tvore dobru kombinaciju za ABBV gel. Mono natrijev citrat upotrebljen je kao puferirajuća tvar koja omogućava blago kiseli pH (4,4), a kao ljekovite tvari upotrebljeni su klotrimazol (antimikotik) i metronidazol (antiprotozoik i antibakterijsko sredstvo), zajedno sa sporama Lactobacillus. Pripravci su upotrebljeni u terapiji miješanih vaginalnih infekcija. Pokusi ex vivo pokazali su da se bioadhezivni gel zadržava u vagini 12-13 sati. Rezultati in vitro ispitivanja ukazuju na to da ABBV gel ima bolje antibakterijsko djelovanje i dulje zadržavanje od intravaginalnog sustava koji je dostupan na tržištu.

Ključne riječi
puferirani gel; vaginalna bioadhezija; bioadhezivni polimeri; miješane vaginalne infekcije

Hrčak ID: 26775

URI
https://hrcak.srce.hr/26775

[engleski]

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