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Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions

Ita Hadžisejdić
Marina Šimat
Ana Bosak
Maja Krašević
Blaženka Grahovac

Puni tekst: engleski, pdf (124 KB) str. 879-883 preuzimanja: 417* citiraj
APA 6th Edition
Hadžisejdić, I., Šimat, M., Bosak, A., Krašević, M. i Grahovac, B. (2006). Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions. Collegium antropologicum, 30 (4), 879-883. Preuzeto s https://hrcak.srce.hr/27649
MLA 8th Edition
Hadžisejdić, Ita, et al. "Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions." Collegium antropologicum, vol. 30, br. 4, 2006, str. 879-883. https://hrcak.srce.hr/27649. Citirano 23.11.2019.
Chicago 17th Edition
Hadžisejdić, Ita, Marina Šimat, Ana Bosak, Maja Krašević i Blaženka Grahovac. "Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions." Collegium antropologicum 30, br. 4 (2006): 879-883. https://hrcak.srce.hr/27649
Harvard
Hadžisejdić, I., et al. (2006). 'Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions', Collegium antropologicum, 30(4), str. 879-883. Preuzeto s: https://hrcak.srce.hr/27649 (Datum pristupa: 23.11.2019.)
Vancouver
Hadžisejdić I, Šimat M, Bosak A, Krašević M, Grahovac B. Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions. Collegium antropologicum [Internet]. 2006 [pristupljeno 23.11.2019.];30(4):879-883. Dostupno na: https://hrcak.srce.hr/27649
IEEE
I. Hadžisejdić, M. Šimat, A. Bosak, M. Krašević i B. Grahovac, "Prevalence of Human Papillomavirus Genotypes in Cervical Cancer and Precursor Lesions", Collegium antropologicum, vol.30, br. 4, str. 879-883, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/27649. [Citirano: 23.11.2019.]

Sažetak
There are no data obtained in biopsy material on the prevalence of human papillomavirus (HPV) and HPV genotypes
in Croatian women with cervical carcinoma and precursor lesions. Therefore, the prevalence of HPV and HPV genotypes
was investigated in archival material of cervical carcinoma and precursor lesions kept at Department of Pathology,
School of Medicine, University of Rijeka. DNA was isolated from formalin fixed, paraffin embedded tissue, histologically
classified as cervical intraepithelial neoplasia (CIN) III (n=43), squamous cell carcinoma (SCC) (n=54) and adenocarcinoma
(ADC) (n=40). HPV testing was performed by polimerase chain reaction (PCR) using generic and genotype
specific primers. The prevalence of HPV DNA was 93.02%, 92.59%, and 92.5% in CIN III, SCC and ADC, respectively. In
CIN III and SCC, HPV-16 was the most common high-risk genotype, identified in 65% and 52%, followed by HPV-18 in
22.5% and 28% of cases, respectively. HPV-18 showed a statistically significant prevalence in ADC (67.6%) as compared
with SCC (2=9.924; p 0.01). Study results revealed a high prevalence of HPV-DNA in examined cervical lesions (>90%).
HPV-16 predominated in SCC and HPV-18 in ADC. Single infection was more frequently present than multiple infections
in all three histological groups.

Ključne riječi
cervical intraepithelial neoplasia; cervical carcinoma; HPV genotype prevalence

Hrčak ID: 27649

URI
https://hrcak.srce.hr/27649

Posjeta: 586 *