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Effects of Raloxifene on Changes in Bone Density

Blaženka Miškić
Dragica Bistrović
Branka Vizner
Vesna Ćosić
Đuro Miškić
Davorka Herman

Puni tekst: engleski, pdf (93 KB) str. 767-770 preuzimanja: 241* citiraj
APA 6th Edition
Miškić, B., Bistrović, D., Vizner, B., Ćosić, V., Miškić, Đ. i Herman, D. (2006). Effects of Raloxifene on Changes in Bone Density. Collegium antropologicum, 30 (4), 767-770. Preuzeto s https://hrcak.srce.hr/27676
MLA 8th Edition
Miškić, Blaženka, et al. "Effects of Raloxifene on Changes in Bone Density." Collegium antropologicum, vol. 30, br. 4, 2006, str. 767-770. https://hrcak.srce.hr/27676. Citirano 26.07.2021.
Chicago 17th Edition
Miškić, Blaženka, Dragica Bistrović, Branka Vizner, Vesna Ćosić, Đuro Miškić i Davorka Herman. "Effects of Raloxifene on Changes in Bone Density." Collegium antropologicum 30, br. 4 (2006): 767-770. https://hrcak.srce.hr/27676
Harvard
Miškić, B., et al. (2006). 'Effects of Raloxifene on Changes in Bone Density', Collegium antropologicum, 30(4), str. 767-770. Preuzeto s: https://hrcak.srce.hr/27676 (Datum pristupa: 26.07.2021.)
Vancouver
Miškić B, Bistrović D, Vizner B, Ćosić V, Miškić Đ, Herman D. Effects of Raloxifene on Changes in Bone Density. Collegium antropologicum [Internet]. 2006 [pristupljeno 26.07.2021.];30(4):767-770. Dostupno na: https://hrcak.srce.hr/27676
IEEE
B. Miškić, D. Bistrović, B. Vizner, V. Ćosić, Đ. Miškić i D. Herman, "Effects of Raloxifene on Changes in Bone Density", Collegium antropologicum, vol.30, br. 4, str. 767-770, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/27676. [Citirano: 26.07.2021.]

Sažetak
Raloxifene hydrochloride therapy effectiveness in bone mineral density (BMD) changes compared to calcium and vitamin
D3 therapy over a 2-year period. Case-control study: a group of 254 women was prescribed raloxifene (raloxifene
hydrochloride) together with calcium and vitamin D3 while other group of 254 women used calcium and vitamin D3
therapy. BMD was measured at the hip, spine and forearm at the beginning and at the end of the 2-year period. Treatment
with raloxifene resulted in a 3.7% increase in BMD at the spine in 98% of examinees. A 1.2% BMD increase was
shown in 75% of examinees at the hip. A 1.2% decrease in BMD at forearm shown in 93% of examinees using raloxifene.
The calcium and vitamin D3 therapy led to an increase in BMD in 58% examinees at the spine, in 56% at the hip and in
38% at the forearm, which was significantly lower than in women using raloxifene. Among women using calcium and
vitamin D alone an average BMD decrease of 1.2% was registered on 42% of examinees at the spine, 2.6% decrease on
46% of examinees at the hip and 4.2% decrease on 35% of examinees at the forearm. Treatment with raloxifene resulted
in a significant increase in BMD at the spine with odds ratio (OR 5.85, p<0.05) compared with calcium and vitamin D3
alone. There was no statistically proven increase in BMD at either the hip (OR 0.015) or forearm (OR 0.122).

Ključne riječi
bone mineral density; osteoporosis; raloxifene; vitamin D3; calcium

Hrčak ID: 27676

URI
https://hrcak.srce.hr/27676

Posjeta: 459 *