Izvorni znanstveni članak
Malignant Potential of Dysplastic Endocervical Epithelium Assessed by Ploidy Status, S-Phase Fraction and C-myc Expression
Ljiljana Hlupić
Stanko Jukić
Dražen Švagelj
Marina Kos
Sažetak
The aim of this study was to determine if dysplastic endocervical cells (EC) posses a
neoplastic potential as precursor lesions to adenocarcinoma in situ (AIS). The malignant
potential was determined by assessing the ploidy status and proliferative activity
by flow cytometry and c-myc expression by immunohistochemistry. The studied parameters
were assessed separately in morphologically normal, dysplastic and malignant EC.
The 2 test showed significant association of malignant EC with aneuploidy (p=0.008)
and high proliferative activity (p=0.042). Since one third of the dysplastic EC are also
aneuploid and show high mitotic activity, they probably have malignant potential as
well. The dysplastic EC showed a significant association with c-myc oncogene expression
(p=0.028). Our results indicate the existence of pre-malignant glandular lesions, while
the immunohistochemical detection of c-myc protooncogene could be helpful in detection
of EC with malignant potential, even without any dysplastic morphological changes.
Ključne riječi
precursor lesions; cervical adenocarcinoma; ploidy; S-phase; c-myc oncogene
Hrčak ID:
28077
URI
Datum izdavanja:
16.6.2003.
Posjeta: 894 *