Izvorni znanstveni članak
Age-Related Skeletal Muscle Atrophy in Humans: An Immunohistochemical and Morphometric Study
M. Nikolić
D. Malnar-Dragojević
D. Bobinac
S. Bajek
R. Jerković
T. Šoić-Vranić
Sažetak
The aim of this study was to determine age-related changes in three human muscles
with different function and location in the body. The cross sectional area and the percentage
of fibers type I, type IIA and type IIX were studied in vastus lateralis, deltoideus
and external intercostal muscle. Muscle samples were obtained from 30 male subjects,
aged 20–80 years. Fiber types were defined immunohistochemically, using monoclonal
antibodies specific for type I, type IIA and type IIX fibers. Cross sectional area of muscle
fibers was analyzed morphometrically by computerized image analysis. All muscle fiber
types (I, IIA, IIX) showed the reduction in the fiber size in all three examined muscles. In
all muscles the proportion of type I and type IIA was changed, but not in type IIX. With
increasing age results showed the increase in proportion of type I, while proportion of
type IIA fibers decreased, with vastus lateralis muscle being the most affected. These results
suggest that age-related muscle atrophy is not a general phenomenon, and does
not affect all muscles equally.
Ključne riječi
Hrčak ID:
28443
URI
Datum izdavanja:
17.12.2001.
Posjeta: 1.346 *