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Kratko priopćenje
https://doi.org/10.2478/v10007-008-0026-z

Učinak ampicilina i klorokina na humoralnu imunošku reakciju na goveđi albumin kapsuliran u liposome

JITENDER MADAN ; Department of Pharmaceutics, Hindu College of Pharmacy, Sonepat (Haryana), India
DINESH KAUSHIK ; Department of Pharmaceutics, Hindu College of Pharmacy, Sonepat (Haryana), India
SATISH SARDANA ; Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana) India
DINA NATH MISHRA ; Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana) India
SHALINDER KUMAR SINGH ; Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana) India
BINOD KUMAR SINGH ; Department of Pharmacy, Kumaon University, Nainital, India

Puni tekst: engleski, pdf (104 KB) str. 479-487 preuzimanja: 501* citiraj
APA 6th Edition
MADAN, J., KAUSHIK, D., SARDANA, S., NATH MISHRA, D., KUMAR SINGH, S. i KUMAR SINGH, B. (2008). Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes. Acta Pharmaceutica, 58 (4), 479-487. https://doi.org/10.2478/v10007-008-0026-z
MLA 8th Edition
MADAN, JITENDER, et al. "Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 479-487. https://doi.org/10.2478/v10007-008-0026-z. Citirano 24.06.2019.
Chicago 17th Edition
MADAN, JITENDER, DINESH KAUSHIK, SATISH SARDANA, DINA NATH MISHRA, SHALINDER KUMAR SINGH i BINOD KUMAR SINGH. "Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes." Acta Pharmaceutica 58, br. 4 (2008): 479-487. https://doi.org/10.2478/v10007-008-0026-z
Harvard
MADAN, J., et al. (2008). 'Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes', Acta Pharmaceutica, 58(4), str. 479-487. doi: https://doi.org/10.2478/v10007-008-0026-z
Vancouver
MADAN J, KAUSHIK D, SARDANA S, NATH MISHRA D, KUMAR SINGH S, KUMAR SINGH B. Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes. Acta Pharm. [Internet]. 2008 [pristupljeno 24.06.2019.];58(4):479-487. doi: https://doi.org/10.2478/v10007-008-0026-z
IEEE
J. MADAN, D. KAUSHIK, S. SARDANA, D. NATH MISHRA, S. KUMAR SINGH i B. KUMAR SINGH, "Effect of ampicillin and chloroquine on humoral immune response elicited by bovine albumin encapsulated in liposomes", Acta Pharmaceutica, vol.58, br. 4, str. 479-487, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0026-z

Sažetak
Na eksperimentalnim životinjama koje su prvo tretirane ampicilinom i klorokinom a zatim imunizirane goveđim serumskim albuminom s liposomima praćena je supresija imunološkog sustava i potencijalna interakcija lijekova. Liposomi su pripravljeni metodom reverzno-fazne evaporacije, a određena im je veličina čestica, količina supstancije koju mogu inkorporirati i oslobađanje in vitro. Humoralna imunološka reakcija praćena je određivanjem titra IgG antitijela ELISA metodom. Rezultati rada pokazuju da liposomi s fosfatidilkolinom iz soje i kolesterolom u molnom omjeru 7:3 imaju prosječni promjer 235.4  10.3 nm i sposobnost inkorporacije 41.3  3.2%. Ampicilin je značajno (p < 0.05) smanjio titar antitijela, a klorokin nije. Ovi će rezultati biti korisni u programiranju novog režima primjene lijekova i u praćenju interakcije između cjepiva i lijeka.

Ključne riječi
imunomodulacija; liposomi; goveđi albumin; ampicilin; klorokin

Hrčak ID: 28797

URI
https://hrcak.srce.hr/28797

[engleski]

Posjeta: 893 *