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https://doi.org/10.2478/v10007-008-0030-3

Reakcija β-amino-α,γ-dicianokrotononitrila s acetofenonom: sinteza derivata piridina, piridazina i tiofena s antimikrobnim djelovanjem

RAFAT M. MOHAREB ; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
KARAM A. El-SHARKAWY ; Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), October, A. R. Egypt
SHERIF M. SHERIF ; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Puni tekst: engleski, pdf (110 KB) str. 429-444 preuzimanja: 929* citiraj
APA 6th Edition
MOHAREB, R.M., El-SHARKAWY, K.A. i SHERIF, S.M. (2008). The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities. Acta Pharmaceutica, 58 (4), 429-444. https://doi.org/10.2478/v10007-008-0030-3
MLA 8th Edition
MOHAREB, RAFAT M., et al. "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 429-444. https://doi.org/10.2478/v10007-008-0030-3. Citirano 26.06.2019.
Chicago 17th Edition
MOHAREB, RAFAT M., KARAM A. El-SHARKAWY i SHERIF M. SHERIF. "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities." Acta Pharmaceutica 58, br. 4 (2008): 429-444. https://doi.org/10.2478/v10007-008-0030-3
Harvard
MOHAREB, R.M., El-SHARKAWY, K.A., i SHERIF, S.M. (2008). 'The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities', Acta Pharmaceutica, 58(4), str. 429-444. doi: https://doi.org/10.2478/v10007-008-0030-3
Vancouver
MOHAREB RM, El-SHARKAWY KA, SHERIF SM. The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities. Acta Pharm. [Internet]. 2008 [pristupljeno 26.06.2019.];58(4):429-444. doi: https://doi.org/10.2478/v10007-008-0030-3
IEEE
R.M. MOHAREB, K.A. El-SHARKAWY i S.M. SHERIF, "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities", Acta Pharmaceutica, vol.58, br. 4, str. 429-444, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0030-3

Sažetak
Kondenzacijom β-amino-α,γ-dicijanokrotononitrila 1 s acetofenonom dobiven je 2-amino-4-fenilpenta-1,3-dien-1,1,3-trikarbonitril (2) koji je upotrebljen u reakcijama heterociklizacije s različitim reagensima poput diazonijevih soli, hidrazina, hidroksilamina i elementarnog sumpora pri čemu su nastali derivati piridazina, pirazola, izoksazola, odnosno tiofena. Spoj 2 je u reakciji s aromatskim aldehidima te naknadno sa cijanometilenima dao derivate piridina. Određene su MIC vrijednosti za novosintetizirane spojeve protiv E. coli, B. cereus, B. subtilis i C. albicans.

Ključne riječi
piridin; izoksazol; piridazin; tiofen; antimikrobno djelovanje

Hrčak ID: 28934

URI
https://hrcak.srce.hr/28934

[engleski]

Posjeta: 1.250 *