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Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid

Biljana Nigović ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Šebojka Komorsky-Lovrić ; Center for Marine and Environmental Research, Ruđer Bošković Institute, Zagreb, Croatia
Dubravka Devčić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (363 KB) str. 453-459 preuzimanja: 1.323* citiraj
APA 6th Edition
Nigović, B., Komorsky-Lovrić, Š. i Devčić, D. (2008). Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid. Croatica Chemica Acta, 81 (3), 453-459. Preuzeto s https://hrcak.srce.hr/31133
MLA 8th Edition
Nigović, Biljana, et al. "Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid." Croatica Chemica Acta, vol. 81, br. 3, 2008, str. 453-459. https://hrcak.srce.hr/31133. Citirano 27.11.2021.
Chicago 17th Edition
Nigović, Biljana, Šebojka Komorsky-Lovrić i Dubravka Devčić. "Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid." Croatica Chemica Acta 81, br. 3 (2008): 453-459. https://hrcak.srce.hr/31133
Harvard
Nigović, B., Komorsky-Lovrić, Š., i Devčić, D. (2008). 'Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid', Croatica Chemica Acta, 81(3), str. 453-459. Preuzeto s: https://hrcak.srce.hr/31133 (Datum pristupa: 27.11.2021.)
Vancouver
Nigović B, Komorsky-Lovrić Š, Devčić D. Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 27.11.2021.];81(3):453-459. Dostupno na: https://hrcak.srce.hr/31133
IEEE
B. Nigović, Š. Komorsky-Lovrić i D. Devčić, "Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid", Croatica Chemica Acta, vol.81, br. 3, str. 453-459, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/31133. [Citirano: 27.11.2021.]

Sažetak
Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzyme
A reductase. The reduction behavior of drug has been studied in different supporting
electrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto the
mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its
direct determination at trace levels has been proposed. The voltammetric response could be
used to determine drug concentration in the range 1.0 × 10–8 to 7.5 × 10–7 mol L–1, with detection
limit of 4.5 × 10–9 mol L–1. Applicability to biological fluid analysis was illustrated. The
method was successfully employed, without sample pretreatment, for quantitation of the active
ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid
identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite
electrode has been examined.

Ključne riječi
simvastatin; square-wave voltammetry; abrasive stripping voltammetry; pharmaceuticals; biological fluid

Hrčak ID: 31133

URI
https://hrcak.srce.hr/31133

Posjeta: 1.723 *