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Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis

Natasa Brijačak
Iva Dekaris
Alenka Gagro
Nikica Gabrić

Puni tekst: engleski, pdf (98 KB) str. 21-25 preuzimanja: 557* citiraj
APA 6th Edition
Brijačak, N., Dekaris, I., Gagro, A. i Gabrić, N. (2008). Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis. Collegium antropologicum, 32 - Supplement 2 (2), 21-25. Preuzeto s https://hrcak.srce.hr/34534
MLA 8th Edition
Brijačak, Natasa, et al. "Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis." Collegium antropologicum, vol. 32 - Supplement 2, br. 2, 2008, str. 21-25. https://hrcak.srce.hr/34534. Citirano 17.06.2021.
Chicago 17th Edition
Brijačak, Natasa, Iva Dekaris, Alenka Gagro i Nikica Gabrić. "Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis." Collegium antropologicum 32 - Supplement 2, br. 2 (2008): 21-25. https://hrcak.srce.hr/34534
Harvard
Brijačak, N., et al. (2008). 'Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis', Collegium antropologicum, 32 - Supplement 2(2), str. 21-25. Preuzeto s: https://hrcak.srce.hr/34534 (Datum pristupa: 17.06.2021.)
Vancouver
Brijačak N, Dekaris I, Gagro A, Gabrić N. Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis. Collegium antropologicum [Internet]. 2008 [pristupljeno 17.06.2021.];32 - Supplement 2(2):21-25. Dostupno na: https://hrcak.srce.hr/34534
IEEE
N. Brijačak, I. Dekaris, A. Gagro i N. Gabrić, "Therapeutic Effect of Amniotic Membrane in Persistent Epithelial Defects and Corneal Ulcers in Herpetic Keratitis", Collegium antropologicum, vol.32 - Supplement 2, br. 2, str. 21-25, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34534. [Citirano: 17.06.2021.]

Sažetak
Amniotic membrane transplantation (AMT) promotes rapid epithelialization and reduces stromal inflammation and
ulceration in HSV-1 keratitis. 18 patients with non-healing epithelial defect or corneal ulcer caused by herpetic keratitis
were included in the study. All patients were treated by AMT. Corneal epithelial cells in patients suffering from herpetic
keratitis secreted 5 ± 4.8 pg/ml of IL-1a and 0.16 ± 0.47 pg/ml of IL-1b (mean ± SD). IL-1a level was significantly higher
as compared to controls (p<0.005). Amniotic membranes that were used to treat investigated patients contained 339.87 ±
105 pg/ml of IL-1ra. In herpetic keratitis pro-inflammatory cytokine IL-1a is secreted from corneal epithelial cells in significantly
higher level then in controls. Beneficial effect of the AMT in such patients could be explained by the fact that
AM secretes its natural antagonist IL-1ra.

Ključne riječi
herpetic keratitis; amniotic membrane; interleukin-1; interleukin-1 receptor antagonist

Hrčak ID: 34534

URI
https://hrcak.srce.hr/34534

Posjeta: 751 *