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Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue
Puni tekst: engleski, pdf (667 KB)
APA 6th Edition
Domijan, A., Peraica, M., Ferenčić, Ž., Čužić, S., Fuchs, R., Lucić, A. i Radić, B. (2004). Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue. Arhiv za higijenu rada i toksikologiju, 55 (4), 243-248. Preuzeto s https://hrcak.srce.hr/252
MLA 8th Edition
Domijan, Ana-Marija, et al. "Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue." Arhiv za higijenu rada i toksikologiju, vol. 55, br. 4, 2004, str. 243-248. https://hrcak.srce.hr/252. Citirano 17.02.2019.
Chicago 17th Edition
Domijan, Ana-Marija, Maja Peraica, Željko Ferenčić, Snježana Čužić, Radovan Fuchs, Ana Lucić i Božica Radić. "Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue." Arhiv za higijenu rada i toksikologiju 55, br. 4 (2004): 243-248. https://hrcak.srce.hr/252
Domijan, A., et al. (2004). 'Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue', Arhiv za higijenu rada i toksikologiju, 55(4), str. 243-248. Preuzeto s: https://hrcak.srce.hr/252 (Datum pristupa: 17.02.2019.)
Domijan A, Peraica M, Ferenčić Ž, Čužić S, Fuchs R, Lucić A i sur. Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue. Arh Hig Rada Toksikol. [Internet]. 2004 [pristupljeno 17.02.2019.];55(4):243-248. Dostupno na: https://hrcak.srce.hr/252
A. Domijan, et al., "Ochratoxin A-Induced Apoptosis in Rat Kidney Tissue", Arhiv za higijenu rada i toksikologiju, vol.55, br. 4, str. 243-248, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/252. [Citirano: 17.02.2019.]
The aim of our study was to find whether ochratoxin A (OTA) induces the apoptosis and/or necrosis of kidney tissue in rats. In the first experiment, the highest number of apoptotic cells was found in rats sacrificed one day after OTA administration (1.00 mg/kg b.w., i.p.). The number of apoptotic cells reduced gradually and they were not seen nine days after OTA administration. A possible dose-dependence of histological changes was checked in kidney tissue of rats given 0.25, 0.50 or 1.00 mg of OTA/kg b.w., i.p. three times a week for four weeks. The number of apoptotic cells showed a clear dose-dependence, but necrosis was absent even at the highest doses.
The time-dependent appearance of lesions related to OTA administration was checked by administering 0.50 mg OTA/kg body weight to rats, and sacrificing them one day after 1, 3, 6, and 9 doses/administrations, or 6 and 21 day after 12 doses/administrations. Long-term administration is associated with continued and increased apoptosis without necrosis, suggestive of OTA’s role in the pathogenesis of progressive renal atrophy.
endemic nephropathy; necrosis; proximal tubules
Hrčak ID: 252
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