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Acta Pharmaceutica, Vol. 59 No. 2, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0018-7

Sinteza kumarinskih heterocikličkih derivata s antioksidativnim djelovanjem i in vitro citotoksično djelovanje na tumorske stanice

PARAMESWARAN MANOJKUMAR ; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamilnadu, India
THENGUNGAL KOCHUPAPPY RAVI ; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamilnadu, India
GOPALAKRISHNAN GOPALAKRISHNAN ; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamilnadu, India

Puni tekst: engleski, pdf (83 KB) str. 159-168 preuzimanja: 1.899* citiraj
APA 6th Edition
MANOJKUMAR, P., RAVI, T.K. i GOPALAKRISHNAN, G. (2009). Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells. Acta Pharmaceutica, 59 (2), 159-168. https://doi.org/10.2478/v10007-009-0018-7
MLA 8th Edition
MANOJKUMAR, PARAMESWARAN, et al. "Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 159-168. https://doi.org/10.2478/v10007-009-0018-7. Citirano 22.02.2019.
Chicago 17th Edition
MANOJKUMAR, PARAMESWARAN, THENGUNGAL KOCHUPAPPY RAVI i GOPALAKRISHNAN GOPALAKRISHNAN. "Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells." Acta Pharmaceutica 59, br. 2 (2009): 159-168. https://doi.org/10.2478/v10007-009-0018-7
Harvard
MANOJKUMAR, P., RAVI, T.K., i GOPALAKRISHNAN, G. (2009). 'Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells', Acta Pharmaceutica, 59(2), str. 159-168. doi: https://doi.org/10.2478/v10007-009-0018-7
Vancouver
MANOJKUMAR P, RAVI TK, GOPALAKRISHNAN G. Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells. Acta Pharm. [Internet]. 2009 [pristupljeno 22.02.2019.];59(2):159-168. doi: https://doi.org/10.2478/v10007-009-0018-7
IEEE
P. MANOJKUMAR, T.K. RAVI i G. GOPALAKRISHNAN, "Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells", Acta Pharmaceutica, vol.59, br. 2, str. 159-168, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0018-7

Sažetak
Cilj rada bio je sintetizirati kumarinske heterocikličke derivate i razjasniti njihovu potencijalnu ulogu kao antioksidativnih i citotoksičnih agenasa na tumorske stanice Daltonovog limfoma (DLA) i Ehrlichove tumorske stanice (EAC). U radu je opisana sinteza kumarinskih derivata s pirazolskim, pirazolonskim, tiazolidin-4-onskim, 5-karboksimetil-4-tiazolidinonskim i 3-acetil-1,3,4-oksadiazolskim prstenom. Hidrazid 4-metilkumarinil-7-oksioctene kiseline (1) dao je u reakciji s derivatima arilazopropana ili hidrazono-3-oksobutirata derivate pirazola (3a-c) i pirazolona (5a-c). Heterociklizacijom Schiffovih baza 1 s tioglikolnom kiselinom, tiojabučnom kiselinom ili anhidridom octene kiseline nastali su heterociklički derivati 4-tiazolidinoni (7a-c), 5-karboksimetil-4-tiazolidinoni (8a-c) i oksadiazoli (9a-c). Neki od spojeva pokazali su obećavajuće rezultate u in vitro testovima za antioksidativno i citostatsko djelovanje na DLA i EAC stanicama pokazali.

Ključne riječi
pirazol; pirazolon; tiazolidin-4-on; oksadiazol; antioksidativno djelovanje

Hrčak ID: 35237

URI
https://hrcak.srce.hr/35237

[engleski]

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