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https://doi.org/10.2478/v10007-009-0016-9

Sinteza derivata pirola kao antimikrobnih tvari

MOSAAD SAYED MOHAMED ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
RAMDAN AHMED EL-DOMANY ; Microbiology and Immunology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
RANIA HELMY ABD EL-HAMEED ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Puni tekst: engleski, pdf (97 KB) str. 145-158 preuzimanja: 1.872* citiraj
APA 6th Edition
SAYED MOHAMED, M., EL-DOMANY, R.A. i ABD EL-HAMEED, R.H. (2009). Synthesis of certain pyrrole derivatives as antimicrobial agents. Acta Pharmaceutica, 59 (2), 145-158. https://doi.org/10.2478/v10007-009-0016-9
MLA 8th Edition
SAYED MOHAMED, MOSAAD, et al. "Synthesis of certain pyrrole derivatives as antimicrobial agents." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 145-158. https://doi.org/10.2478/v10007-009-0016-9. Citirano 20.06.2019.
Chicago 17th Edition
SAYED MOHAMED, MOSAAD, RAMDAN AHMED EL-DOMANY i RANIA HELMY ABD EL-HAMEED. "Synthesis of certain pyrrole derivatives as antimicrobial agents." Acta Pharmaceutica 59, br. 2 (2009): 145-158. https://doi.org/10.2478/v10007-009-0016-9
Harvard
SAYED MOHAMED, M., EL-DOMANY, R.A., i ABD EL-HAMEED, R.H. (2009). 'Synthesis of certain pyrrole derivatives as antimicrobial agents', Acta Pharmaceutica, 59(2), str. 145-158. doi: https://doi.org/10.2478/v10007-009-0016-9
Vancouver
SAYED MOHAMED M, EL-DOMANY RA, ABD EL-HAMEED RH. Synthesis of certain pyrrole derivatives as antimicrobial agents. Acta Pharm. [Internet]. 2009 [pristupljeno 20.06.2019.];59(2):145-158. doi: https://doi.org/10.2478/v10007-009-0016-9
IEEE
M. SAYED MOHAMED, R.A. EL-DOMANY i R.H. ABD EL-HAMEED, "Synthesis of certain pyrrole derivatives as antimicrobial agents", Acta Pharmaceutica, vol.59, br. 2, str. 145-158, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0016-9

Sažetak
U radu je opisana sinteza novih derivata pirola i pirolo[2,3-d]pirimidina s poboljšanim antimikrobnim djelovanjem. Reakcijom benzoina, primarnih aromatskih amina i malononitrila sintetizirana je serija novih 2-aminopirol-3-karbonitrila (1a-d), iz kojih su potom pripravljeni derivati pirola (2a-d do 5a-d) i pirolo[2,3-d]pirimidina (6a-d do 10a,d). Sintetiziranim spojevima ispitano je in vitro antimikrobno djelovanje na različite Gram pozitivne, Gram negativne bakterije i gljivice. Neki od sintetiziranih spojeva [2-amino-1-(2-metilfenil)-4,5-difenil-1H-pirol-3-karbonitril (1b), 2-amino-3-karbamoil-1-(3-metilfenil)-4,5-difenil-1H-pirol (2b), N-(3-cijano-1-(2-metilfenil)-4,5-difenil-1H-pirol-2-il)-acetamid (3b), N-(3-cijano-1-(3-metilfenil)-4,5-difenil-1H-pirol-2-il)-acetamid (3c), 2-amino-1-(4-metoksifenil)-4,5-difenil-3-tetrazolo-1H-pirol (5d), 7-(4-metoksifenil)-5,6-difenil-7H-pirolo[2,3-d]pirimidin-4(3H)-on (7d), 7(3-metilfenil)-5,6-difenil-7H-pirolo[2,3-d]pirimidin-4(3H)-tion (9b) i N-(7-(2-metilfenil)-5,6-difenil-7H-pirolo[2,3-d]pirimidin)-N-aril amin (10a)] imaju snažno antimikrobno djelovanje.

Ključne riječi
pirol; pirolopirimidin; antimikrobno djelovanje

Hrčak ID: 35239

URI
https://hrcak.srce.hr/35239

[engleski]

Posjeta: 2.247 *