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Kratko priopćenje
https://doi.org/10.2478/v10007-009-0026-7

Sinteza novih derivata triazola kao anti-nociceptivnih i protuuaplnih agenasa

AIYALU RAJASEKARAN ; KMCH College of Pharmacy, Coimbatore, Tamilnadu, India
KALASALINGAM ANANDA RAJAGOPAL ; AK College of Pharmacy, Krishnankoil, Tamilnadu, India

Puni tekst: engleski, pdf (82 KB) str. 355-364 preuzimanja: 1.626* citiraj
APA 6th Edition
RAJASEKARAN, A. i RAJAGOPAL, K.A. (2009). Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents. Acta Pharmaceutica, 59 (3), 355-364. https://doi.org/10.2478/v10007-009-0026-7
MLA 8th Edition
RAJASEKARAN, AIYALU i KALASALINGAM ANANDA RAJAGOPAL. "Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 355-364. https://doi.org/10.2478/v10007-009-0026-7. Citirano 16.06.2019.
Chicago 17th Edition
RAJASEKARAN, AIYALU i KALASALINGAM ANANDA RAJAGOPAL. "Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents." Acta Pharmaceutica 59, br. 3 (2009): 355-364. https://doi.org/10.2478/v10007-009-0026-7
Harvard
RAJASEKARAN, A., i RAJAGOPAL, K.A. (2009). 'Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents', Acta Pharmaceutica, 59(3), str. 355-364. doi: https://doi.org/10.2478/v10007-009-0026-7
Vancouver
RAJASEKARAN A, RAJAGOPAL KA. Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents. Acta Pharm. [Internet]. 2009 [pristupljeno 16.06.2019.];59(3):355-364. doi: https://doi.org/10.2478/v10007-009-0026-7
IEEE
A. RAJASEKARAN i K.A. RAJAGOPAL, "Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents", Acta Pharmaceutica, vol.59, br. 3, str. 355-364, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0026-7

Sažetak
Sintetizirano je osam novih 1-[2-(1H-tetrazol-5-il)etil]-1H-benzo[d][1,2,3]triazola (3a-h), s potencijalnim anti-nociceptivnim i protuupalnim djelovanjem. Navedeni spojevi pripravljeni su kondenzacijom 1-[2-(1H-tetrazol-5-il)etil]-1H-benzotriazola (2) i odgovarajućih kiselinskih klorida. Spoj 2 dobiven je reakcijom 3-(1H-benzo[d][1,2,3]triazol-1-il)propanonitrila (1) s natrijevim azidom i amonijevim kloridom u prisutnosti dimetilformamida. Sintetizirani spojevi su karakterizirani spektroskopskim metodama (IR, 1H NMR, spektroskopijom masa) i elementarnom analizom. Anti-nociceptivno djelovanje ispitivano je metodom vruće ploče i praćenjem odgovora na bolne podražaje, dok je protuupalno djelovanje evaluirano testom s karageninom. 5-(2-(1H-benzo[d][1,2,3]triazo-1-il)etil)-1H-tetrazol-1-il)(4-aminofenil)metanon (3d) i 5-(2-(1H-benzo[d][1,2,3]triazo-1-il)etil)-1H-tetrazol-1-il) (2-hidroksifenil)metanon (3g) pokazali su značajno anti-nociceptivno djelovanje. 1-(2-(1-Tosil-1H-tetrazol-5-il)etil)-1H-benzo[d][1,2,3]triazol (3c) i 4-5-(2-(1H-benzo[d][1,2,3]triazo-1-il)etil)-1H-tetrazol-1-il sulfonil)benzenamin (3f) pokazali su superiorno protuupalno djelovanje u odnosu na druge sintetizirane spojeve. Daljnja istraživanja su nužna kako bi se razjasnio mehanizam djelovanja.

Ključne riječi
sinteza; 1-[2-(1H-tetrazol-5-il)etil]-1H-benzo[d][1,2,3]triazol; nocicepcija; upala

Hrčak ID: 38922

URI
https://hrcak.srce.hr/38922

[engleski]

Posjeta: 1.948 *