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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0027-6

Metaloantibiotici: Sinteza, karakterizacija i antimikrobno djelovanje kompleksa fluorokinolona s bizmutom na Helicobacter pylori

ANWAR R. SHAIKH ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
RAJANI GIRIDHAR ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
FRANCIS MEGRAUD ; Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux cedex, France
MANGE RAM YADAV ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India

Puni tekst: engleski, pdf (179 KB) str. 259-271 preuzimanja: 897* citiraj
APA 6th Edition
SHAIKH, A.R., GIRIDHAR, R., MEGRAUD, F. i YADAV, M.R. (2009). Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori. Acta Pharmaceutica, 59 (3), 259-271. https://doi.org/10.2478/v10007-009-0027-6
MLA 8th Edition
SHAIKH, ANWAR R., et al. "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 259-271. https://doi.org/10.2478/v10007-009-0027-6. Citirano 23.02.2019.
Chicago 17th Edition
SHAIKH, ANWAR R., RAJANI GIRIDHAR, FRANCIS MEGRAUD i MANGE RAM YADAV. "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori." Acta Pharmaceutica 59, br. 3 (2009): 259-271. https://doi.org/10.2478/v10007-009-0027-6
Harvard
SHAIKH, A.R., et al. (2009). 'Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori', Acta Pharmaceutica, 59(3), str. 259-271. doi: https://doi.org/10.2478/v10007-009-0027-6
Vancouver
SHAIKH AR, GIRIDHAR R, MEGRAUD F, YADAV MR. Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori. Acta Pharm. [Internet]. 2009 [pristupljeno 23.02.2019.];59(3):259-271. doi: https://doi.org/10.2478/v10007-009-0027-6
IEEE
A.R. SHAIKH, R. GIRIDHAR, F. MEGRAUD i M.R. YADAV, "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori", Acta Pharmaceutica, vol.59, br. 3, str. 259-271, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0027-6

Sažetak
Komplesacijom fluorokinolona, norfloksacina, ofloksacina, ciprofloksacina, sparfloksacina, lomefloksacina, pefloksacina i gatifloksacina s bizmutom pripravljeni su novi organometalni spojevi. Dobiveni kompleksi karakterizirani su UV, IR i atomskom apsorpcijskom spektroskopijom, elementarnom analizom, diferencijalnom pretražnom kalorimetrijom, termogravimetrijskom analizom i spektrometrijom masa. Nadalje, ispitivan je njihov učinak na Helicobacter pylori i druge mikroorganizme. Ispitivani spojevi pokazuju snažno djelovanje na Helicobacter pylori u koncentraciji 0,5 mg Ll te umjereno djelovanje na Escherichia coli, Staphylococcus aureus, Bacillus pumilus i Staphylococcus epidermidis. Kompleksi fluorokinolona s bizmutom potencijalni su lijekovi za infekcije uzrokovane H. pylori.

Ključne riječi
fluorokinolon; bizmut; kompleks; antimikrobno djelovanje; Helicobacter pylory

Hrčak ID: 39122

URI
https://hrcak.srce.hr/39122

[engleski]

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