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Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution

Biserka Prugovečki ; Laboratory of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10 000 Zagreb, Croatia
Eleanor J. Dodson ; York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW England
Guy G. Dodson ; York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW England
Dubravka Matković-Čalogović ; Laboratory of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10 000 Zagreb, Croatia

Puni tekst: engleski, pdf (3 MB) str. 433-438 preuzimanja: 681* citiraj
APA 6th Edition
Prugovečki, B., Dodson, E.J., Dodson, G.G. i Matković-Čalogović, D. (2009). Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution. Croatica Chemica Acta, 82 (2), 433-438. Preuzeto s https://hrcak.srce.hr/39660
MLA 8th Edition
Prugovečki, Biserka, et al. "Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution." Croatica Chemica Acta, vol. 82, br. 2, 2009, str. 433-438. https://hrcak.srce.hr/39660. Citirano 07.04.2020.
Chicago 17th Edition
Prugovečki, Biserka, Eleanor J. Dodson, Guy G. Dodson i Dubravka Matković-Čalogović. "Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution." Croatica Chemica Acta 82, br. 2 (2009): 433-438. https://hrcak.srce.hr/39660
Harvard
Prugovečki, B., et al. (2009). 'Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution', Croatica Chemica Acta, 82(2), str. 433-438. Preuzeto s: https://hrcak.srce.hr/39660 (Datum pristupa: 07.04.2020.)
Vancouver
Prugovečki B, Dodson EJ, Dodson GG, Matković-Čalogović D. Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution. Croatica Chemica Acta [Internet]. 2009 [pristupljeno 07.04.2020.];82(2):433-438. Dostupno na: https://hrcak.srce.hr/39660
IEEE
B. Prugovečki, E.J. Dodson, G.G. Dodson i D. Matković-Čalogović, "Structure of the T6 Human Nickel Insulin Derivative at 1.35 Å Resolution", Croatica Chemica Acta, vol.82, br. 2, str. 433-438, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/39660. [Citirano: 07.04.2020.]

Sažetak
This paper presents results of the structural investigation on the human insulin hexamer derivative stabilised by nickel coordination. Single crystals of the Ni-insulin derivative were prepared by the hanging drop vapour diffusion crystallisation method using metal-free insulin and nickel(II) acetate tetrahydrate. The low-temperature crystal structure was determined by the single crystal X-ray crystallographic method with data extending to 1.35 Å spacing. The investigated insulin derivative exhibits the T6 form of insulin and crystallizes in the trigonal system in space group R3, with the unit cell parameters a = b = 81.41 Å and c = 33.75 Å. There are two nickel atoms per insulin hexamer and both are octahedrally coordinated by three Nε2 atoms of three symmetry-related HisB10/HisD10 and three oxygen atoms of three symmetry-related water molecules.

Ključne riječi
insulin derivative; nickel; X-ray structure

Hrčak ID: 39660

URI
https://hrcak.srce.hr/39660

Posjeta: 916 *