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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Kratko priopćenje
https://doi.org/10.2478/v10007-009-0030-y

Sterodin®, novi imunostimulator: neka toksikološka i farmakološka vrednovanja in vivo i interakcija lijek-lipid in vitro

SARBANI DEY RAY ; Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur-713206, India
PARTHA PRATIM ROY ; Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India
SUPRATIM RAY ; Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur-713206, India

Puni tekst: engleski, pdf (84 KB) str. 325-334 preuzimanja: 1.166* citiraj
APA 6th Edition
RAY, S.D., ROY, P.P. i RAY, S. (2009). Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro. Acta Pharmaceutica, 59 (3), 325-334. https://doi.org/10.2478/v10007-009-0030-y
MLA 8th Edition
RAY, SARBANI DEY, et al. "Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 325-334. https://doi.org/10.2478/v10007-009-0030-y. Citirano 23.02.2019.
Chicago 17th Edition
RAY, SARBANI DEY, PARTHA PRATIM ROY i SUPRATIM RAY. "Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro." Acta Pharmaceutica 59, br. 3 (2009): 325-334. https://doi.org/10.2478/v10007-009-0030-y
Harvard
RAY, S.D., ROY, P.P., i RAY, S. (2009). 'Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro', Acta Pharmaceutica, 59(3), str. 325-334. doi: https://doi.org/10.2478/v10007-009-0030-y
Vancouver
RAY SD, ROY PP, RAY S. Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro. Acta Pharm. [Internet]. 2009 [pristupljeno 23.02.2019.];59(3):325-334. doi: https://doi.org/10.2478/v10007-009-0030-y
IEEE
S.D. RAY, P.P. ROY i S. RAY, "Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro", Acta Pharmaceutica, vol.59, br. 3, str. 325-334, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0030-y

Sažetak
Sterodin® je novi nespecifični imunostimulator koji sadrži žučne lipide i bakterijske metabolite. U radu su opisana neka njegova toksikološka i farmakološka svojstva in vivo, te interakcija lijek-lipid in vitro. Nadalje, proučavana je moguća peroksidacija lipida inducirana Sterodinom® te učinak askorbinske kiseline na tu peroksidaciju. LD50 Sterodina bio je 0,63 mL u mužjacima albino miševa mase 20 g (31,50 mL kg-1 tjelesne mase). U istim životinjama Sterodin® je povećao ukupan broj leukocita i neutrofila (59 odnosno 26 % mjereno 6 dana nakon injekcije Sterodina®) i stimulirao aktivnost fagocita in vivo. U ispitivanjima interakcije lijek-lipid in vitro korištena je jetra koze kao izvor lipida. Rezultati ukazuju da Sterodin® inducira peroksidaciju lipida, koja se može spriječiti askorbinskom kiselinom.

Ključne riječi
Sterodin; imunostimulator; askorbinska kisleina; peroksidacija lipida; malondialdehid; reducirani glutation

Hrčak ID: 39665

URI
https://hrcak.srce.hr/39665

[engleski]

Posjeta: 1.502 *