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Original scientific paper
https://doi.org/10.2478/v10007-010-0001-3

Priprava i evaluacija dvofazičnih plutajućih tableta fenoverina

SURESH BANDARI ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
CHANDRA MOHAN EAGA ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
ASHOK THADISHETTY ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
MADHUSUDAN RAO YAMSANI ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India

Fulltext: english, pdf (100 KB) pages 89-97 downloads: 1.021* cite
APA 6th Edition
BANDARI, S., EAGA, C.M., THADISHETTY, A. & YAMSANI, M.R. (2010). Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine. Acta Pharmaceutica, 60 (1), 89-97. https://doi.org/10.2478/v10007-010-0001-3
MLA 8th Edition
BANDARI, SURESH, et al. "Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine." Acta Pharmaceutica, vol. 60, no. 1, 2010, pp. 89-97. https://doi.org/10.2478/v10007-010-0001-3. Accessed 27 Nov. 2020.
Chicago 17th Edition
BANDARI, SURESH, CHANDRA MOHAN EAGA, ASHOK THADISHETTY and MADHUSUDAN RAO YAMSANI. "Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine." Acta Pharmaceutica 60, no. 1 (2010): 89-97. https://doi.org/10.2478/v10007-010-0001-3
Harvard
BANDARI, S., et al. (2010). 'Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine', Acta Pharmaceutica, 60(1), pp. 89-97. https://doi.org/10.2478/v10007-010-0001-3
Vancouver
BANDARI S, EAGA CM, THADISHETTY A, YAMSANI MR. Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine. Acta Pharm. [Internet]. 2010 [cited 2020 November 27];60(1):89-97. https://doi.org/10.2478/v10007-010-0001-3
IEEE
S. BANDARI, C.M. EAGA, A. THADISHETTY and M.R. YAMSANI, "Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine", Acta Pharmaceutica, vol.60, no. 1, pp. 89-97, 2010. [Online]. https://doi.org/10.2478/v10007-010-0001-3

Abstracts
U radu je opisan razvoj bifazičnog sustava za isporuku fenoverina s produljenim zadržavanjem u želucu radi održavanja konstantne koncentracije lijeka u plazmi. Sustav je dobiven metodom izravne kompresije, a sastoji se od tablete za inicijalno doziranje i matriksne tablete za plutanje. Oslobađanje lijeka iz bifazičnog GRDDS u 0,1 mol L1 HCl i SGF (bez enzima) bilo je produljeno više od 12 h, a sustav je pokazao plutajuća svojstva. Ispitivanja stabilnosti pokazala su da nema značajne promjene u profilu oslobađanja (f2 > 50). Na temelju kinetike oslobađanja može se zaključiti da su plutajuće višeslojne matriksne tablete s HPMC posebno pogodan sustav za isporuku fenoverina u želucu s kinetikom oslobađanja nultog reda.

Keywords
bifazično oslobađanje; zadržavanje u želucu; višeslojne matriksne tablete; kinetika oslobađanja

Hrčak ID: 41962

URI
https://hrcak.srce.hr/41962

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