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Pregledni rad
https://doi.org/10.2478/10004-1254-60-2009-1992

Toxicological Properties of Citrinin

Dubravka Flajs ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Maja Peraica ; Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (95 KB) str. 457-463 preuzimanja: 734* citiraj
APA 6th Edition
Flajs, D. i Peraica, M. (2009). Toxicological Properties of Citrinin. Arhiv za higijenu rada i toksikologiju, 60 (4), 457-463. https://doi.org/10.2478/10004-1254-60-2009-1992
MLA 8th Edition
Flajs, Dubravka i Maja Peraica. "Toxicological Properties of Citrinin." Arhiv za higijenu rada i toksikologiju, vol. 60, br. 4, 2009, str. 457-463. https://doi.org/10.2478/10004-1254-60-2009-1992. Citirano 07.03.2021.
Chicago 17th Edition
Flajs, Dubravka i Maja Peraica. "Toxicological Properties of Citrinin." Arhiv za higijenu rada i toksikologiju 60, br. 4 (2009): 457-463. https://doi.org/10.2478/10004-1254-60-2009-1992
Harvard
Flajs, D., i Peraica, M. (2009). 'Toxicological Properties of Citrinin', Arhiv za higijenu rada i toksikologiju, 60(4), str. 457-463. https://doi.org/10.2478/10004-1254-60-2009-1992
Vancouver
Flajs D, Peraica M. Toxicological Properties of Citrinin. Arh Hig Rada Toksikol. [Internet]. 2009 [pristupljeno 07.03.2021.];60(4):457-463. https://doi.org/10.2478/10004-1254-60-2009-1992
IEEE
D. Flajs i M. Peraica, "Toxicological Properties of Citrinin", Arhiv za higijenu rada i toksikologiju, vol.60, br. 4, str. 457-463, 2009. [Online]. https://doi.org/10.2478/10004-1254-60-2009-1992

Sažetak
Citrinin (CTN) is a nephrotoxic mycotoxin produced by several fungal strains belonging to the genera Penicillium, Aspergillus, and Monascus. It contaminates various commodities of plant origin, cereals in particular, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A (OTA).
These two mycotoxins are believed to be involved in the aetiology of endemic nephropathy. In addition to nephrotoxicity, CTN is also embryocidal and fetotoxic. The genotoxic properties of CTN have been demonstrated with the micronuleus test (MN), but not with single-cell gel electrophoresis. The mechanism of CTN toxicity is not fully understood, especially not whether CTN toxicity and genotoxicity are the consequence of oxidative stress or of increased permeability of mitochondrial membranes. CTN requires complex cellular biotransformation to exert mutagenicity.
Compared with other mycotoxins, CTN contamination of food and feed is rather scarce. However, it is reasonable to believe that humans are much more frequently exposed to CTN than generally accepted, because it is produced by the same moulds as OTA, which is a common contaminant of human food all over the world.
At present, there are no specifi c regulations either in Croatia or in the European Union concerning CTN in any kind of commodity.

Ključne riječi
mycotoxin; nephrotoxicity; organic anion; oxidative stress

Hrčak ID: 45393

URI
https://hrcak.srce.hr/45393

[hrvatski]

Posjeta: 1.245 *