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Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report

Slavica Dodig   ORCID icon orcid.org/0000-0002-3419-5171 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia
Renata Zrinski Topić ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia
Jadranka Demirović ; Clinical Laboratory, University Hospital for Tumors, Zagreb, Croatia
Jadranka Živčić ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia

Puni tekst: engleski, pdf (99 KB) str. 97-100 preuzimanja: 248* citiraj
APA 6th Edition
Dodig, S., Zrinski Topić, R., Demirović, J. i Živčić, J. (2010). Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report. Biochemia Medica, 20 (1), 97-100. Preuzeto s https://hrcak.srce.hr/47855
MLA 8th Edition
Dodig, Slavica, et al. "Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report." Biochemia Medica, vol. 20, br. 1, 2010, str. 97-100. https://hrcak.srce.hr/47855. Citirano 05.04.2020.
Chicago 17th Edition
Dodig, Slavica, Renata Zrinski Topić, Jadranka Demirović i Jadranka Živčić. "Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report." Biochemia Medica 20, br. 1 (2010): 97-100. https://hrcak.srce.hr/47855
Harvard
Dodig, S., et al. (2010). 'Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report', Biochemia Medica, 20(1), str. 97-100. Preuzeto s: https://hrcak.srce.hr/47855 (Datum pristupa: 05.04.2020.)
Vancouver
Dodig S, Zrinski Topić R, Demirović J, Živčić J. Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report. Biochemia Medica [Internet]. 2010 [pristupljeno 05.04.2020.];20(1):97-100. Dostupno na: https://hrcak.srce.hr/47855
IEEE
S. Dodig, R. Zrinski Topić, J. Demirović i J. Živčić, "Increased IgA in a subject with positive anti-thyroid autoantibodies – a case report", Biochemia Medica, vol.20, br. 1, str. 97-100, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/47855. [Citirano: 05.04.2020.]
Puni tekst: hrvatski, pdf (99 KB) str. 97-100 preuzimanja: 238* citiraj
APA 6th Edition
Dodig, S., Zrinski Topić, R., Demirović, J. i Živčić, J. (2010). Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja. Biochemia Medica, 20 (1), 97-100. Preuzeto s https://hrcak.srce.hr/47855
MLA 8th Edition
Dodig, Slavica, et al. "Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja." Biochemia Medica, vol. 20, br. 1, 2010, str. 97-100. https://hrcak.srce.hr/47855. Citirano 05.04.2020.
Chicago 17th Edition
Dodig, Slavica, Renata Zrinski Topić, Jadranka Demirović i Jadranka Živčić. "Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja." Biochemia Medica 20, br. 1 (2010): 97-100. https://hrcak.srce.hr/47855
Harvard
Dodig, S., et al. (2010). 'Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja', Biochemia Medica, 20(1), str. 97-100. Preuzeto s: https://hrcak.srce.hr/47855 (Datum pristupa: 05.04.2020.)
Vancouver
Dodig S, Zrinski Topić R, Demirović J, Živčić J. Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja. Biochemia Medica [Internet]. 2010 [pristupljeno 05.04.2020.];20(1):97-100. Dostupno na: https://hrcak.srce.hr/47855
IEEE
S. Dodig, R. Zrinski Topić, J. Demirović i J. Živčić, "Povećane vrijednosti IgA u bolesnice s pozitivnim antitireoidnim autoantitijelima - prikaz slučaja", Biochemia Medica, vol.20, br. 1, str. 97-100, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/47855. [Citirano: 05.04.2020.]

Sažetak
Introduction: Increased concentrations of antithyroid autoantibodies are found in inflammatory diseases as well as in thyroid autoimmune disorders. The aim of this report is to present increased IgA concentrations in a female patient with positive anti-thyroid autoantibodies. Results throughout 13 months of follow-up are presented.
Materials and methods: The levels of thyroid hormones and antibodies in the serum samples were measured using microparticle enzyme-immunoas-say. IgA was determined by two immunochemical methods, immuno-turbi-dimetric method and radial immunodiffusion, respectively.
Results: Initial thyroid function tests showed normal values of T3, T4 and thyroid stimulating hormone (TSH), and increased values of thyroid peroxi-dase autoantibodies (anti-TPO), anti-thyroglobulin (anti-Tg) autoantibodies and IgA. The patient underwent treatment with single daily dose of levot-hyroxine. The elevated initial levels of anti-TPO stabilized with the administration of levothyroxine, while anti-Tg remained increased. IgA determined by immuno-turbidimetric method was significantly increased during the follow-up period. Repeated determination of IgA by radial immunodiffusion revealed lower IgA concentrations.
Conclusion: Possible false increased IgA values could be a result of both, interferences of goat anti-IgA antibodies from reagents, and cross-reactivity with endogenous anti-Tg autoantibodies in serum, respectively. Further investigations are needed to ascertain the cause of increased IgA values in patient with positive anti-thyroid autoantibodies.

Ključne riječi
IgA; immunoassay; interferences; thyroid disease; autoantibody

Hrčak ID: 47855

URI
https://hrcak.srce.hr/47855

[hrvatski]

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