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Original scientific paper

Sinteza N4-(2,4-dimetilfenil) semikarbazona kao inhibitori 4-aminobutirat aminotransferaze

PERUMAL YOGEESWARI
DHARMARAJAN SRIRAM
RATHINASABAPATHY THIRUMURUGAN
LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT
JEGADEESAN VAIGUNDA RAGAVENDRAN
RAMKUMAR KAVYA
KAVYA RAKHRA
VIVEK SARASWAT

Fulltext: english, pdf (97 KB) pages 259-272 downloads: 781* cite
APA 6th Edition
YOGEESWARI, P., SRIRAM, D., THIRUMURUGAN, R., JIT, L.R.J.S.J., RAGAVENDRAN, J.V., KAVYA, R., ... SARASWAT, V. (2006). Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharmaceutica, 56 (3), 259-272. Retrieved from https://hrcak.srce.hr/4539
MLA 8th Edition
YOGEESWARI, PERUMAL, et al. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica, vol. 56, no. 3, 2006, pp. 259-272. https://hrcak.srce.hr/4539. Accessed 23 Jul. 2019.
Chicago 17th Edition
YOGEESWARI, PERUMAL, DHARMARAJAN SRIRAM, RATHINASABAPATHY THIRUMURUGAN, LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT, JEGADEESAN VAIGUNDA RAGAVENDRAN, RAMKUMAR KAVYA, KAVYA RAKHRA and VIVEK SARASWAT. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica 56, no. 3 (2006): 259-272. https://hrcak.srce.hr/4539
Harvard
YOGEESWARI, P., et al. (2006). 'Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors', Acta Pharmaceutica, 56(3), pp. 259-272. Available at: https://hrcak.srce.hr/4539 (Accessed 23 July 2019)
Vancouver
YOGEESWARI P, SRIRAM D, THIRUMURUGAN R, JIT LRJSJ, RAGAVENDRAN JV, KAVYA R, et al. Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharm. [Internet]. 2006 [cited 2019 July 23];56(3):259-272. Available from: https://hrcak.srce.hr/4539
IEEE
P. YOGEESWARI, et al., "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors", Acta Pharmaceutica, vol.56, no. 3, pp. 259-272, 2006. [Online]. Available: https://hrcak.srce.hr/4539. [Accessed: 23 July 2019]

Abstracts
Sintetizirano je nekoliko 2,4-dimetilfenil supstituiranih semikarbazona u tri sintetska koraka koji uključuju aril uree i aril semikarbazide. Strukture spojeva su potvrđene spektroskopskim metoda i elementarnom analizom. Ispitano je antikonvulzivno djelovanje novih spojeva nakon izazivanja konvulzija elektrošokom te supkutanom primjenom pentilentetrazola ili strihnina. Osim toga, testirano je antidepresivno djelovanje te učinak tih spojeva na ponašanje štakora. Praćen je njihov utjecaj na koncentraciju gama-aminomaslačne kiseline (GABA) u mozgu štakora te in vitro na aktivnost gama-aminobutirat transaminaze (Pseudomonas fluorescens). Preliminarni pokusi ukazuju da antikonvulzivno djelovanje ovih spojeva uključuje GABA-ergički sustav.

Keywords
2,4-dimetilfenil semikarbazoni; antikonvulzivi; GABA; GABA-transaminaza; maksimalni elektrošok; pentilentetrazol; strihnin

Hrčak ID: 4539

URI
https://hrcak.srce.hr/4539

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