hrcak mascot   Srce   HID

Acta Pharmaceutica, Vol. 56 No. 3, 2006.

Izvorni znanstveni članak

Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

PERUMAL YOGEESWARI
DHARMARAJAN SRIRAM
RATHINASABAPATHY THIRUMURUGAN
LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT
JEGADEESAN VAIGUNDA RAGAVENDRAN
RAMKUMAR KAVYA
KAVYA RAKHRA
VIVEK SARASWAT

Puni tekst: engleski, pdf (97 KB) str. 259-272 preuzimanja: 776* citiraj
APA 6th Edition
YOGEESWARI, P., SRIRAM, D., THIRUMURUGAN, R., JIT, L.R.J.S.J., RAGAVENDRAN, J.V., KAVYA, R., ... SARASWAT, V. (2006). Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharmaceutica, 56 (3), 259-272. Preuzeto s https://hrcak.srce.hr/4539
MLA 8th Edition
YOGEESWARI, PERUMAL, et al. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica, vol. 56, br. 3, 2006, str. 259-272. https://hrcak.srce.hr/4539. Citirano 22.05.2019.
Chicago 17th Edition
YOGEESWARI, PERUMAL, DHARMARAJAN SRIRAM, RATHINASABAPATHY THIRUMURUGAN, LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT, JEGADEESAN VAIGUNDA RAGAVENDRAN, RAMKUMAR KAVYA, KAVYA RAKHRA i VIVEK SARASWAT. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica 56, br. 3 (2006): 259-272. https://hrcak.srce.hr/4539
Harvard
YOGEESWARI, P., et al. (2006). 'Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors', Acta Pharmaceutica, 56(3), str. 259-272. Preuzeto s: https://hrcak.srce.hr/4539 (Datum pristupa: 22.05.2019.)
Vancouver
YOGEESWARI P, SRIRAM D, THIRUMURUGAN R, JIT LRJSJ, RAGAVENDRAN JV, KAVYA R i sur. Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharm. [Internet]. 2006 [pristupljeno 22.05.2019.];56(3):259-272. Dostupno na: https://hrcak.srce.hr/4539
IEEE
P. YOGEESWARI, et al., "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors", Acta Pharmaceutica, vol.56, br. 3, str. 259-272, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4539. [Citirano: 22.05.2019.]

Sažetak
Several 2,4-dimethylphenyl substituted semicarbazones were synthesized in three steps involving aryl urea and aryl semicarbazide formations. The structures were confirmed by spectral and elemental analyses. All the compounds were evaluated for anticonvulsant activity by using a series of test models including maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ) and subcutaneous strychnine (scSTY) seizure threshold tests. The compounds were also evaluated for behavioural impairement and depression activity. In the neurochemical investigation, potent compounds were evaluated for their effects on rat brain -aminobutyric acid levels and in vitro -aminobutyrate transaminase (Pseudomonas fluorescens) activity. Preliminary studies suggest these compounds to exhibit anticonvulsant activity via GABA-mediated mechanism.

Ključne riječi
2,4-dimethylphenyl semicarbazones; anticonvulsants; GABA; GABA-transaminase; maximal electroshock; pentylenetetrazole; strychinine

Hrčak ID: 4539

URI
https://hrcak.srce.hr/4539

[hrvatski]

Posjeta: 1.175 *