hrcak mascot   Srce   HID

Original scientific paper

In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels

MOHAMED MAHMOUD NOUNOU
LABIBA K. EL-KHORDAGUI
NAWAL A. KHALAFALLAH
SAID A. KHALIL

Fulltext: english, pdf (135 KB) pages 311-324 downloads: 8.558* cite
APA 6th Edition
NOUNOU, M.M., EL-KHORDAGUI, L.K., KHALAFALLAH, N.A. & KHALIL, S.A. (2006). In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. Acta Pharmaceutica, 56 (3), 311-324. Retrieved from https://hrcak.srce.hr/4542
MLA 8th Edition
NOUNOU, MOHAMED MAHMOUD, et al. "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels." Acta Pharmaceutica, vol. 56, no. 3, 2006, pp. 311-324. https://hrcak.srce.hr/4542. Accessed 24 Jul. 2019.
Chicago 17th Edition
NOUNOU, MOHAMED MAHMOUD, LABIBA K. EL-KHORDAGUI, NAWAL A. KHALAFALLAH and SAID A. KHALIL. "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels." Acta Pharmaceutica 56, no. 3 (2006): 311-324. https://hrcak.srce.hr/4542
Harvard
NOUNOU, M.M., et al. (2006). 'In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels', Acta Pharmaceutica, 56(3), pp. 311-324. Available at: https://hrcak.srce.hr/4542 (Accessed 24 July 2019)
Vancouver
NOUNOU MM, EL-KHORDAGUI LK, KHALAFALLAH NA, KHALIL SA. In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. Acta Pharm. [Internet]. 2006 [cited 2019 July 24];56(3):311-324. Available from: https://hrcak.srce.hr/4542
IEEE
M.M. NOUNOU, L.K. EL-KHORDAGUI, N.A. KHALAFALLAH and S.A. KHALIL, "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels", Acta Pharmaceutica, vol.56, no. 3, pp. 311-324, 2006. [Online]. Available: https://hrcak.srce.hr/4542. [Accessed: 24 July 2019]

Abstracts
A method for determining the rate of hydrophilic and hydrophobic drug entities release from different types of liposomal dispersions and gels using a dialysis method is described. Dibucaine base and 5-fluorouracil were used as model drugs for a hydrophobic and hydrophilic drug, respectively. A dialysis technique was employed. Release rates were affected by the rate of rotation of the paddles of the tablet dissolution tester, temperature, and volume of release medium. The method was used to evaluate the in vitro drug release from hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. The in vitro release study of dibucaine base showed no burst effect, while the in vitro release study of 5-fluorouracil showed a clear burst effect with an initial fast release phase followed by a sustained release phase.

Keywords
dibucaine; 5-fluorouracil; in vitro release; release stability; liposomal gel; Higuchi diffusion model

Hrčak ID: 4542

URI
https://hrcak.srce.hr/4542

[croatian]

Visits: 9.085 *