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Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation
A. K. TIWARY
Puni tekst: engleski, pdf (100 KB)
APA 6th Edition
SHARMA, G., JAIN, S., TIWARY, A.K. i KAUR, G. (2006). Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation. Acta Pharmaceutica, 56 (3), 337-345. Preuzeto s https://hrcak.srce.hr/4544
MLA 8th Edition
SHARMA, GARIMA, et al. "Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation." Acta Pharmaceutica, vol. 56, br. 3, 2006, str. 337-345. https://hrcak.srce.hr/4544. Citirano 17.02.2019.
Chicago 17th Edition
SHARMA, GARIMA, S. JAIN, A. K. TIWARY i GURPREET KAUR. "Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation." Acta Pharmaceutica 56, br. 3 (2006): 337-345. https://hrcak.srce.hr/4544
SHARMA, G., et al. (2006). 'Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation', Acta Pharmaceutica, 56(3), str. 337-345. Preuzeto s: https://hrcak.srce.hr/4544 (Datum pristupa: 17.02.2019.)
SHARMA G, JAIN S, TIWARY AK, KAUR G. Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation. Acta Pharm. [Internet]. 2006 [pristupljeno 17.02.2019.];56(3):337-345. Dostupno na: https://hrcak.srce.hr/4544
G. SHARMA, S. JAIN, A.K. TIWARY i G. KAUR, "Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation", Acta Pharmaceutica, vol.56, br. 3, str. 337-345, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4544. [Citirano: 17.02.2019.]
In this study, a bioadhesive dosage form of clotrimazole was designed using a combination of bioadhesive polymers Carbopol 934P, sodium carboxymethylcellulose and sodium alginate in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablets from porcine vaginal mucosal membrane. The strong interaction between polymer and mucus lining of the tissue helps in increasing the contact time and permits localization of activity. Carbopol 934P showed maximum bioadhesion and required maximum force for detachment; the force required for detachment was directly proportional to its content. The formulations were tested for their swelling behavior using agar gel plate method. The swelling index was a function of the concentration of the hydrophilic polymer and the formulations containing Carbopol 934 P and sodium carboxy methylcellulose were found to swell to a greater extent than those containing carbopol and sodium alginate. In vitro release studies showed that the batch consisting 2: 1 ratio of Carbopol 934P: sodium alginate (batch C3) released clotrimazole over 24 h. The similarity factor showed that the dissolution profiles of fresh and aged tablets was similar, suggesting good stability of vaginal tablets prepared using a combination of Carbopol 934P and sodium alginate.
bioadhesives; vaginal tablets; clotrimazole; Carbopol 934P; sodium alginate; sodium carboxymethylcellulose
Hrčak ID: 4544
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