Acta Pharmaceutica, Vol. 56 No. 3, 2006.
Izvorni znanstveni članak
Once daily bioadhesive vaginal clotrimazole tablets: Design and evaluation
GARIMA SHARMA
S. JAIN
A. K. TIWARY
GURPREET KAUR
Sažetak
In this study, a bioadhesive dosage form of clotrimazole was designed using a combination of bioadhesive polymers Carbopol 934P, sodium carboxymethylcellulose and sodium alginate in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablets from porcine vaginal mucosal membrane. The strong interaction between polymer and mucus lining of the tissue helps in increasing the contact time and permits localization of activity. Carbopol 934P showed maximum bioadhesion and required maximum force for detachment; the force required for detachment was directly proportional to its content. The formulations were tested for their swelling behavior using agar gel plate method. The swelling index was a function of the concentration of the hydrophilic polymer and the formulations containing Carbopol 934 P and sodium carboxy methylcellulose were found to swell to a greater extent than those containing carbopol and sodium alginate. In vitro release studies showed that the batch consisting 2: 1 ratio of Carbopol 934P: sodium alginate (batch C3) released clotrimazole over 24 h. The similarity factor showed that the dissolution profiles of fresh and aged tablets was similar, suggesting good stability of vaginal tablets prepared using a combination of Carbopol 934P and sodium alginate.
Ključne riječi
bioadhesives; vaginal tablets; clotrimazole; Carbopol 934P; sodium alginate; sodium carboxymethylcellulose
Hrčak ID:
4544
URI
Datum izdavanja:
1.9.2006.
Posjeta: 3.705 *