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Acta Pharmaceutica, Vol. 56 No. 3, 2006.

Izvorni znanstveni članak

A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms

NAFISUR RAHMAN
NISHAT ANWAR
MOHAMMAD KASHIF
NASRUL HODA

Puni tekst: engleski, pdf (107 KB) str. 347-357 preuzimanja: 1.035* citiraj
APA 6th Edition
RAHMAN, N., ANWAR, N., KASHIF, M. i HODA, N. (2006). A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms. Acta Pharmaceutica, 56 (3), 347-357. Preuzeto s https://hrcak.srce.hr/4545
MLA 8th Edition
RAHMAN, NAFISUR, et al. "A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms." Acta Pharmaceutica, vol. 56, br. 3, 2006, str. 347-357. https://hrcak.srce.hr/4545. Citirano 25.05.2019.
Chicago 17th Edition
RAHMAN, NAFISUR, NISHAT ANWAR, MOHAMMAD KASHIF i NASRUL HODA. "A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms." Acta Pharmaceutica 56, br. 3 (2006): 347-357. https://hrcak.srce.hr/4545
Harvard
RAHMAN, N., et al. (2006). 'A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms', Acta Pharmaceutica, 56(3), str. 347-357. Preuzeto s: https://hrcak.srce.hr/4545 (Datum pristupa: 25.05.2019.)
Vancouver
RAHMAN N, ANWAR N, KASHIF M, HODA N. A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms. Acta Pharm. [Internet]. 2006 [pristupljeno 25.05.2019.];56(3):347-357. Dostupno na: https://hrcak.srce.hr/4545
IEEE
N. RAHMAN, N. ANWAR, M. KASHIF i N. HODA, "A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms", Acta Pharmaceutica, vol.56, br. 3, str. 347-357, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4545. [Citirano: 25.05.2019.]

Sažetak
A simple and sensitive kinetic spectrophotometric method has been developed. The method is based on the reduction of Fe(III) with captopril. Fe(II) then reacts with potassium ferricyanide, resulting in the formation of a blue product. The reaction is followed spectrophotometrically by measuring the rate of change of absorbance at 730 nm. Thus, 1.23 × 10-3 mol L-1 FeCl3 and 3.04 × 10-4 mol L-1 potassium ferricyanide were used as optimum values for maximum concentration of captopril in the calibration graph. The initial rate is utilized for constructing the calibration graph, which was found to be linear in the range 4.60 × 10–6–5.06 × 10–5 mol L-1; detection limit is 1.99 × 10–7 mol L-1. The proposed method has been validated; the mean recovery ranges from 99.8–101.4% with RSD < 2%. Common excipients do not interfere with the determination. The point and interval hypotheses tests have been performed and confirmed that there is no significant difference between the proposed method and conventional spectrophotometric method. The experimental true bias of all samples is lower than ± 2.0%. The proposed method has been applied to the determination of captopril in bulk and dosage forms.

Ključne riječi
captopril; determination; kinetic spectrophotometric method

Hrčak ID: 4545

URI
https://hrcak.srce.hr/4545

[hrvatski]

Posjeta: 1.678 *