hrcak mascot   Srce   HID

Short communication, Note
https://doi.org/10.2478/v10007-010-0006-y

Pretraživanje tradicionalnih europskih ljekovitih biljaka na inhibiciju acetilkolinesteraze i butirilkolinesteraze

NATALIA WSZELAKI ; Institute of Pharmacy, Free University of Berlin, D-14195 Berlin, Germany
AGNIESZKA KUCIUN ; Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, 02-098 Warsaw, Poland
ANNA KAROLINA KISS ; Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, 02-098 Warsaw, Poland

Fulltext: english, pdf (87 KB) pages 119-128 downloads: 1.133* cite
APA 6th Edition
WSZELAKI, N., KUCIUN, A. & KISS, A.K. (2010). Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta Pharmaceutica, 60 (1), 119-128. https://doi.org/10.2478/v10007-010-0006-y
MLA 8th Edition
WSZELAKI, NATALIA, et al. "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity." Acta Pharmaceutica, vol. 60, no. 1, 2010, pp. 119-128. https://doi.org/10.2478/v10007-010-0006-y. Accessed 16 Jul. 2019.
Chicago 17th Edition
WSZELAKI, NATALIA, AGNIESZKA KUCIUN and ANNA KAROLINA KISS. "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity." Acta Pharmaceutica 60, no. 1 (2010): 119-128. https://doi.org/10.2478/v10007-010-0006-y
Harvard
WSZELAKI, N., KUCIUN, A., and KISS, A.K. (2010). 'Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity', Acta Pharmaceutica, 60(1), pp. 119-128. doi: https://doi.org/10.2478/v10007-010-0006-y
Vancouver
WSZELAKI N, KUCIUN A, KISS AK. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta Pharm. [Internet]. 2010 [cited 2019 July 16];60(1):119-128. doi: https://doi.org/10.2478/v10007-010-0006-y
IEEE
N. WSZELAKI, A. KUCIUN and A.K. KISS, "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity", Acta Pharmaceutica, vol.60, no. 1, pp. 119-128, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0006-y

Abstracts
Inhibitori acetilkolinesteraze (AChE) povećavaju kolinergičku transmisiju u mozgu, pa se koriste za simptomatsko liječenje Alzheimerove bolesti (AD). S druge strane, inhibitori butirilkolinesteraze (BuChE) značajno povećavaju ekstracelularnu količinu AChE u mozgu, a da pri tome ne uzrokuju snažne nuspojave ni u središnjem ni i perifernom živčanom sustavu. Galantamin, jedan od odobrenih AChE inhibitora, alkaloid iz lukovica narcisa, pokazuje da su biljke značajni izvor novih potencijalnih AChE- i BuChE- inhibitora. U ovom radu, ispitivali smo učinak dvanaest biljaka koje se koriste u tradicionalnoj europskoj medicini na različite poremećaje središnjeg živčanog sustava i na poboljšanje pamćenja. Pomoću Ellmanove kolorimetrijske metode praćen je inhibitorni učinak metanolnih i heksanskih ekstrakata tih biljaka na AChE i BuChE. Najjači inhibitorni učinak pokazali su heksanski ekstrakti cvjetova Arnica chamissonis Less. susb. foliosa i nadzemnih dijelova Ruta graveolens L. u koncentraciji od 400 μg mL1. Međutim, metanolni ekstrakti cvjetova Arnica chamissonis Less. susb. foliosa i nadzemnih dijelova Hypericum perforatum L. u istim koncentracijama pokazuju selektivnu inhibiciju samo na AChE. Ostali ekstrakti bili su nedjelotvorni. Rezultati ukazuju na potrebu daljnjih ispitivanja ekstrakata arnike, rute i gospine trave da se utvrdi koji su sastojci ekstrakata odgovorni za inhibiciju AChE i BuChE.

Keywords
inhibicija acetilkolinesteraze; inhibicija butirilkolinesteraze; tradicionalna medicina

Hrčak ID: 48280

URI
https://hrcak.srce.hr/48280

[english]

Visits: 1.857 *