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https://doi.org/10.2478/v10007-010-0008-9

Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

NIRAV V. PATEL ; Anand Pharmacy College, Anand, Gujarat-388 001, India
JAYVADAN K. PATEL ; Nootan Pharmacy College, Visnagar, Gujarat-384 315, India
SHREERAJ H. SHAH ; L. J. Institute of Pharmacy, Ahmedabad, Gujarat-382 210, India

Puni tekst: engleski, pdf (181 KB) str. 39-54 preuzimanja: 1.354* citiraj
APA 6th Edition
PATEL, N.V., PATEL, J.K. i SHAH, S.H. (2010). Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine. Acta Pharmaceutica, 60 (1), 39-54. https://doi.org/10.2478/v10007-010-0008-9
MLA 8th Edition
PATEL, NIRAV V., et al. "Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine." Acta Pharmaceutica, vol. 60, br. 1, 2010, str. 39-54. https://doi.org/10.2478/v10007-010-0008-9. Citirano 16.06.2019.
Chicago 17th Edition
PATEL, NIRAV V., JAYVADAN K. PATEL i SHREERAJ H. SHAH. "Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine." Acta Pharmaceutica 60, br. 1 (2010): 39-54. https://doi.org/10.2478/v10007-010-0008-9
Harvard
PATEL, N.V., PATEL, J.K., i SHAH, S.H. (2010). 'Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine', Acta Pharmaceutica, 60(1), str. 39-54. doi: https://doi.org/10.2478/v10007-010-0008-9
Vancouver
PATEL NV, PATEL JK, SHAH SH. Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine. Acta Pharm. [Internet]. 2010 [pristupljeno 16.06.2019.];60(1):39-54. doi: https://doi.org/10.2478/v10007-010-0008-9
IEEE
N.V. PATEL, J.K. PATEL i S.H. SHAH, "Box-Behnken experimental design in the development of pectin–compritol ATO 888 compression coated colon targeted drug delivery of mesalamine", Acta Pharmaceutica, vol.60, br. 1, str. 39-54, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0008-9

Sažetak
The aim of this study was to investigate the combined influence of 3 independent variables in the compression coated tablet of mesalamine for ulcerative colitis. A 3-factor, 3-level Box-Behnken design was used to derive a second order polynomial equation and construct contour plots to predict responses. The independent variables selected were: percentage of polymers (pectin and compritol ATO 888) in compression coating (X1), coating mass (X2) and coating force (X3). Fifteen batches were prepared and evaluated for percent of drug released in 5 h (Y5), time required for 50 % mesalamine to disolve (t50) with rat cecal (RC) content and without rat cecal content (t50), percent of drug released in 24 h in the presence of rat cecal content (Y24 with RC). Transformed values of independent and dependent variables were subjected to multiple regressions to establish a full-model second-order polynomial equation. F was calculated to confirm the omission of insignificant terms from the full-model equation. The computer optimization process and contour plots predicted the levels of independent variables X1, X2, and X3 (0, 0.2 and –0.15 respectively) for colon targeting and total percent of drug released up to 24 h.

Ključne riječi
mesalamine; compression coated tablet; colon targeting; drug release study; compritol ATO 888; pectin; Box-Behnken experimental design

Hrčak ID: 48282

URI
https://hrcak.srce.hr/48282

[hrvatski]

Posjeta: 1.679 *