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Original scientific paper
https://doi.org/10.2478/v10007-010-0010-2

RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions

RITESH N. SHARMA ; S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva-382711, Gujarat, India
SHYAM S. PANCHOLI ; S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva-382711, Gujarat, India

Fulltext: english, pdf (166 KB) pages 13-24 downloads: 1.943* cite
APA 6th Edition
SHARMA, R.N. & PANCHOLI, S.S. (2010). RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions. Acta Pharmaceutica, 60 (1), 13-24. https://doi.org/10.2478/v10007-010-0010-2
MLA 8th Edition
SHARMA, RITESH N. and SHYAM S. PANCHOLI. "RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions." Acta Pharmaceutica, vol. 60, no. 1, 2010, pp. 13-24. https://doi.org/10.2478/v10007-010-0010-2. Accessed 24 Nov. 2020.
Chicago 17th Edition
SHARMA, RITESH N. and SHYAM S. PANCHOLI. "RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions." Acta Pharmaceutica 60, no. 1 (2010): 13-24. https://doi.org/10.2478/v10007-010-0010-2
Harvard
SHARMA, R.N., and PANCHOLI, S.S. (2010). 'RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions', Acta Pharmaceutica, 60(1), pp. 13-24. https://doi.org/10.2478/v10007-010-0010-2
Vancouver
SHARMA RN, PANCHOLI SS. RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions. Acta Pharm. [Internet]. 2010 [cited 2020 November 24];60(1):13-24. https://doi.org/10.2478/v10007-010-0010-2
IEEE
R.N. SHARMA and S.S. PANCHOLI, "RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions", Acta Pharmaceutica, vol.60, no. 1, pp. 13-24, 2010. [Online]. https://doi.org/10.2478/v10007-010-0010-2

Abstracts
A simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C18 column with the mobile phase composed of methanol, acetonitrile and water (60:15:25, V/V/V, pH 3.5 by orthophosphoric acid) at 260 nm using a photodiode array detector. The method was linear over the concentration range of 1–18 µg mL 1 and precise with RSD < 1% in intra- and inter-day study. Excellent recoveries of 99.3 ± 0.9 to 100.8 ± 1.2 % proved the accuracy of the method. Developed method was specific, as indicated by chromatographic resolution > 2.0 for each peak and sensitive with LOD 0.03 µg mL−1 and LOQ 0.1 µg mL−1. The method was used to study the drug degradation behavior under forced conditions. Four degradation products (DP-I, II, III, IV) were formed during the degradation study in 0.1 mol L−1 HCl whereas only DP-I, II and III were formed in water, 0.01 mol L−1 NaOH and 3 % H2O2. No significant thermal or photolytic degradation was observed in solid drug. The method was applied successfully for the assay of olmesartan medoxomil in the tablet dosage form.

Keywords
olmesartan medoxomil; forced degradation; high performance liquid chromatography; stability

Hrčak ID: 48284

URI
https://hrcak.srce.hr/48284

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