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Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives

HAYAM H. SAYED
AHMED H. SHAMROUKH
AYMN E. RASHAD

Puni tekst: engleski, pdf (96 KB) str. 231-244 preuzimanja: 1.993* citiraj
APA 6th Edition
SAYED, H.H., SHAMROUKH, A.H. i RASHAD, A.E. (2006). Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives. Acta Pharmaceutica, 56 (2), 231-244. Preuzeto s https://hrcak.srce.hr/4558
MLA 8th Edition
SAYED, HAYAM H., et al. "Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives." Acta Pharmaceutica, vol. 56, br. 2, 2006, str. 231-244. https://hrcak.srce.hr/4558. Citirano 18.10.2019.
Chicago 17th Edition
SAYED, HAYAM H., AHMED H. SHAMROUKH i AYMN E. RASHAD. "Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives." Acta Pharmaceutica 56, br. 2 (2006): 231-244. https://hrcak.srce.hr/4558
Harvard
SAYED, H.H., SHAMROUKH, A.H., i RASHAD, A.E. (2006). 'Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives', Acta Pharmaceutica, 56(2), str. 231-244. Preuzeto s: https://hrcak.srce.hr/4558 (Datum pristupa: 18.10.2019.)
Vancouver
SAYED HH, SHAMROUKH AH, RASHAD AE. Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives. Acta Pharm. [Internet]. 2006 [pristupljeno 18.10.2019.];56(2):231-244. Dostupno na: https://hrcak.srce.hr/4558
IEEE
H.H. SAYED, A.H. SHAMROUKH i A.E. RASHAD, "Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives", Acta Pharmaceutica, vol.56, br. 2, str. 231-244, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4558. [Citirano: 18.10.2019.]

Sažetak
4,6-Diamino-1H-pyrimidine-2-thione (1) was used for the preparation of the pyrimidine derivatives 2-5. Compound 5 was cyclized to produce pyrimido[2,1-b][1,3]thiazine derivatives 6, which was condensed with p-chlorobenzaldehyde to give compound 7. The latter compound was reacted with hydroxylamine to give isoxazolo[4,5-d]thiazino[2,3-a]pyrimidines 8. Compound 8b was treated with 2-chloroethyl methyl ether to afford compound 9. Similarly, compound 3 was reacted with chloroacetic acid to give thiazolo[3,2-a]pyrimidine 10, which was condensed with p-chlorobenzaldehyde to give compound 11. Compound 11 was condensed with hydroxylamine to give isoxazolo[4,5-d]thiazolo[2,3-a]pyrimidine 12. Compound 12b was treated with 2-chloroethyl methyl ether to afford compound 13. The biological evaluation of some prepared products showed that many of them revealed promising antimicrobial activity.

Ključne riječi
pyrimidine; pyrimidothiazine; thiazolopyrimidine; antimicrobial activity

Hrčak ID: 4558

URI
https://hrcak.srce.hr/4558

[hrvatski]

Posjeta: 2.580 *