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Short communication, Note

Esterifikacija teofilin octene kiseline s dietilenglikol monometil eterom

BOIKA TSVETKOVA
JASMINA TENCHEVA
PLAMEN PEIKOV

Fulltext: english, pdf (116 KB) pages 251-257 downloads: 1.880* cite
APA 6th Edition
TSVETKOVA, B., TENCHEVA, J. & PEIKOV, P. (2006). Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharmaceutica, 56 (2), 251-257. Retrieved from https://hrcak.srce.hr/4560
MLA 8th Edition
TSVETKOVA, BOIKA, et al. "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether." Acta Pharmaceutica, vol. 56, no. 2, 2006, pp. 251-257. https://hrcak.srce.hr/4560. Accessed 21 Jul. 2019.
Chicago 17th Edition
TSVETKOVA, BOIKA, JASMINA TENCHEVA and PLAMEN PEIKOV. "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether." Acta Pharmaceutica 56, no. 2 (2006): 251-257. https://hrcak.srce.hr/4560
Harvard
TSVETKOVA, B., TENCHEVA, J., and PEIKOV, P. (2006). 'Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether', Acta Pharmaceutica, 56(2), pp. 251-257. Available at: https://hrcak.srce.hr/4560 (Accessed 21 July 2019)
Vancouver
TSVETKOVA B, TENCHEVA J, PEIKOV P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. [Internet]. 2006 [cited 2019 July 21];56(2):251-257. Available from: https://hrcak.srce.hr/4560
IEEE
B. TSVETKOVA, J. TENCHEVA and P. PEIKOV, "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether", Acta Pharmaceutica, vol.56, no. 2, pp. 251-257, 2006. [Online]. Available: https://hrcak.srce.hr/4560. [Accessed: 21 July 2019]

Abstracts
U radu je proučavana kinetika esterifikacije 7-teofiln octene kiseline s dietilenglikol monometileterom u prisutnosti dicikloheksilkarbodiimida i 4-dimetilaminopiridina kao katalizatora. Prema poznatom mehanizmu, pored glavne reakcije esterifikacije, zbiva se i sporedna reakcija u kojoj intramolekularnom pregradnjom nastaje farmakolški aktivna N-acilurea. Tijek glavne i sporedne reakcije praćen je pomoću RP-HPLC s UV detekcijom, uz kvantifikaciju estera i uree. Praćen je utjecaj koncentracije reaktanata (kiseline, alkohola i katalizatora) na reakciju esterifikacije i sporedne reakcije te su pronađeni reakcijski uvjeti za usmjeravanje sinteze prema esteru ili ureii. Obje reakcije slijede kinetiku prvog reda. U radu su određene njihove konstante brzine.

Keywords
ester 7-teofilin octene kiseline; N-acilurea; dicikloheksilkarbodiimid; 4-dimetilaminopiridin; esterifikacija; kinetika

Hrčak ID: 4560

URI
https://hrcak.srce.hr/4560

[english]

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