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Acta Pharmaceutica, Vol. 60 No. 2, 2010.

Kratko priopćenje
https://doi.org/10.2478/v10007-010-0011-1

Sinteza i anthelmintičko djelovanje novih 2-supstituiranih-4,5-difenil imidazola

Satyajit Dutta ; Department of Pharmacy, IIMT College of Medical Sciences, ‘O’Pocket, Ganga Nagar, Mawana Road, Meerut-250001, Uttar Pradesh, India

Puni tekst: engleski, pdf (63 KB) str. 229-235 preuzimanja: 837* citiraj
APA 6th Edition
Dutta, S. (2010). Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. Acta Pharmaceutica, 60 (2), 229-235. https://doi.org/10.2478/v10007-010-0011-1
MLA 8th Edition
Dutta, Satyajit. "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 229-235. https://doi.org/10.2478/v10007-010-0011-1. Citirano 23.02.2019.
Chicago 17th Edition
Dutta, Satyajit. "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles." Acta Pharmaceutica 60, br. 2 (2010): 229-235. https://doi.org/10.2478/v10007-010-0011-1
Harvard
Dutta, S. (2010). 'Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles', Acta Pharmaceutica, 60(2), str. 229-235. doi: https://doi.org/10.2478/v10007-010-0011-1
Vancouver
Dutta S. Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. Acta Pharm. [Internet]. 2010 [pristupljeno 23.02.2019.];60(2):229-235. doi: https://doi.org/10.2478/v10007-010-0011-1
IEEE
S. Dutta, "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles", Acta Pharmaceutica, vol.60, br. 2, str. 229-235, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0011-1

Sažetak
Refluksiranjem benzila s različitim supstituiranim aldehidima u prisutnosti amonijeva acetata i ledene octene kiseline sintetizirana je serija 2-supstituiranih-4,5-difenil imidazola (1a-j). Strukture sintetiziranih spojeva potvrđene su IR, 1H NMR i masenom spektroskopijom. U testovima na anthelmintičko djelovanje određeno je vrijeme paralize 0,24 do 1,54 min i vrijeme smrti 0,39 do 4,40 min, dok standarni lijekovi albendazol i piperazin citrat imaju vrijeme paralize 0,54 i 0,58 min, a vrijeme smrti 2,16, odnosno 2,47 min pri istim koncentracijama (1 % m/V). Pet spojeva, 2-[2-hidroksifenil]-4,5-difenil imidazol (1b), 2-[3-metoksifenil]-4,5-difenil imidazol (1c), 2-[2-feniletenil]-4,5-difenil imidazol (1e), 2-[4-fluorofenil]-4,5-difenil imidazol (1g) i 2-[3-nitrofenil]-4,5-difenil imidazol (1h) pokazuju značajno anthelmintičko djelovanje u odnosnu na standardne lijekove.

Ključne riječi
2-supstituirani-4,5-difenil imidazoli; anthelmintik; antiparazitik

Hrčak ID: 48386

URI
https://hrcak.srce.hr/48386

[engleski]

Posjeta: 1.081 *