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Kratko priopćenje
https://doi.org/10.2478/v10007-010-0011-1

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

Satyajit Dutta ; Department of Pharmacy, IIMT College of Medical Sciences, ‘O’Pocket, Ganga Nagar, Mawana Road, Meerut-250001, Uttar Pradesh, India

Puni tekst: engleski, pdf (63 KB) str. 229-235 preuzimanja: 876* citiraj
APA 6th Edition
Dutta, S. (2010). Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. Acta Pharmaceutica, 60 (2), 229-235. https://doi.org/10.2478/v10007-010-0011-1
MLA 8th Edition
Dutta, Satyajit. "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 229-235. https://doi.org/10.2478/v10007-010-0011-1. Citirano 16.06.2019.
Chicago 17th Edition
Dutta, Satyajit. "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles." Acta Pharmaceutica 60, br. 2 (2010): 229-235. https://doi.org/10.2478/v10007-010-0011-1
Harvard
Dutta, S. (2010). 'Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles', Acta Pharmaceutica, 60(2), str. 229-235. doi: https://doi.org/10.2478/v10007-010-0011-1
Vancouver
Dutta S. Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. Acta Pharm. [Internet]. 2010 [pristupljeno 16.06.2019.];60(2):229-235. doi: https://doi.org/10.2478/v10007-010-0011-1
IEEE
S. Dutta, "Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles", Acta Pharmaceutica, vol.60, br. 2, str. 229-235, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0011-1

Sažetak
A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral data. Compounds 1a-j were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 s and death time of 0.39 to 4.40 s while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 s and death time of 2.16 and 2.47 s, respectively, at the same concentration of 1 % (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.

Ključne riječi
2-substituted-4,5-diphenyl imidazoles; anthelmintic; antiparasitic

Hrčak ID: 48386

URI
https://hrcak.srce.hr/48386

[hrvatski]

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