hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-61-2010-1979

Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver

Seema Sharma ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut, India
Suresh Vir Singh Rana ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut, India

Puni tekst: engleski, pdf (300 KB) str. 11-17 preuzimanja: 314* citiraj
APA 6th Edition
Sharma, S. i Rana, S.V.S. (2010). Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver. Arhiv za higijenu rada i toksikologiju, 61 (1), 11-17. https://doi.org/10.2478/10004-1254-61-2010-1979
MLA 8th Edition
Sharma, Seema i Suresh Vir Singh Rana. "Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver." Arhiv za higijenu rada i toksikologiju, vol. 61, br. 1, 2010, str. 11-17. https://doi.org/10.2478/10004-1254-61-2010-1979. Citirano 16.06.2019.
Chicago 17th Edition
Sharma, Seema i Suresh Vir Singh Rana. "Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver." Arhiv za higijenu rada i toksikologiju 61, br. 1 (2010): 11-17. https://doi.org/10.2478/10004-1254-61-2010-1979
Harvard
Sharma, S., i Rana, S.V.S. (2010). 'Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver', Arhiv za higijenu rada i toksikologiju, 61(1), str. 11-17. doi: https://doi.org/10.2478/10004-1254-61-2010-1979
Vancouver
Sharma S, Rana SVS. Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver. Arh Hig Rada Toksikol. [Internet]. 2010 [pristupljeno 16.06.2019.];61(1):11-17. doi: https://doi.org/10.2478/10004-1254-61-2010-1979
IEEE
S. Sharma i S.V.S. Rana, "Melatonin Inhibits Benzene-Induced Lipid Peroxidation in Rat Liver", Arhiv za higijenu rada i toksikologiju, vol.61, br. 1, str. 11-17, 2010. [Online]. doi: https://doi.org/10.2478/10004-1254-61-2010-1979

Sažetak
We studied the antioxidative role of melatonin against benzene toxicity in rat liver. The inhibition of mitochondrial and microsomal lipid peroxidation differed between 24-hour (single-dose), 15-day, and
30-day treatments. Inhibition of mitochondrial lipid peroxidation was the highest after the single dose of melatonin, whereas highest microsomal inhibition was recorded after 30 days of melatonin treatment. No signifi cant difference was recorded between 15-day and 30-day treatments. Cytochrome P4502E1 (CYP4502E1) activity declined after the single-dose and 15-day melatonin treatment in the benzenetreated group, but it rose again, though not signifi cantly after 30 days of treatment. Liver histopathology generally supported these fi ndings. Phenol concentration in the urine samples declined in melatonin and benzene-treated rats. Our results show that melatonin affects CYP4502E1, which is responsible for benzene metabolism. Inhibition of its metabolism correlated with lower lipid peroxidation. In conclusion, melatonin was found to be protective against lipid peroxidation induced by benzene.

Ključne riječi
CYP4502E1; GSH; histopathology; mitochondria; microsomes; phenol; urine

Hrčak ID: 49012

URI
https://hrcak.srce.hr/49012

[hrvatski]

Posjeta: 923 *