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Acta Pharmaceutica, Vol. 60 No. 2, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0019-6

Impact of superdisintegrants on efavirenz release from tablet formulations

Yelchuri Vijaya Rajesh ; RA Chem Pharma Limited, Road No 18, IDA, Nacharam, Hyderabad-500076, India
Jagdish Balasubramaniam ; RA Chem Pharma Limited, Road No 18, IDA, Nacharam, Hyderabad-500076, India
Koduri Bindu ; International Specialty Products India Pvt Limited, 6-3-1090/A, Bhupal Towers, Rajbhavan Road, Somajiguda, Hyderabad-500082, India
Ramachandran Sridevi ; International Specialty Products India Pvt Limited, 6-3-1090/A, Bhupal Towers, Rajbhavan Road, Somajiguda, Hyderabad-500082, India
Maroju Swetha ; International Specialty Products India Pvt Limited, 6-3-1090/A, Bhupal Towers, Rajbhavan Road, Somajiguda, Hyderabad-500082, India
Vinay Umesh Rao ; Daewoong Pharmaceutical Co., Ltd., Indian Branch Office, C-54/A, Techni Towers, IVth floor, A.P.I.E., Balanagar, Hyderabad-500037, India

Puni tekst: engleski, pdf (139 KB) str. 185-195 preuzimanja: 1.057* citiraj
APA 6th Edition
Rajesh, Y.V., Balasubramaniam, J., Bindu, K., Sridevi, R., Swetha, M. i Rao, V.U. (2010). Impact of superdisintegrants on efavirenz release from tablet formulations. Acta Pharmaceutica, 60 (2), 185-195. https://doi.org/10.2478/v10007-010-0019-6
MLA 8th Edition
Rajesh, Yelchuri Vijaya, et al. "Impact of superdisintegrants on efavirenz release from tablet formulations." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 185-195. https://doi.org/10.2478/v10007-010-0019-6. Citirano 15.02.2019.
Chicago 17th Edition
Rajesh, Yelchuri Vijaya, Jagdish Balasubramaniam, Koduri Bindu, Ramachandran Sridevi, Maroju Swetha i Vinay Umesh Rao. "Impact of superdisintegrants on efavirenz release from tablet formulations." Acta Pharmaceutica 60, br. 2 (2010): 185-195. https://doi.org/10.2478/v10007-010-0019-6
Harvard
Rajesh, Y.V., et al. (2010). 'Impact of superdisintegrants on efavirenz release from tablet formulations', Acta Pharmaceutica, 60(2), str. 185-195. doi: https://doi.org/10.2478/v10007-010-0019-6
Vancouver
Rajesh YV, Balasubramaniam J, Bindu K, Sridevi R, Swetha M, Rao VU. Impact of superdisintegrants on efavirenz release from tablet formulations. Acta Pharm. [Internet]. 2010 [pristupljeno 15.02.2019.];60(2):185-195. doi: https://doi.org/10.2478/v10007-010-0019-6
IEEE
Y.V. Rajesh, J. Balasubramaniam, K. Bindu, R. Sridevi, M. Swetha i V.U. Rao, "Impact of superdisintegrants on efavirenz release from tablet formulations", Acta Pharmaceutica, vol.60, br. 2, str. 185-195, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0019-6

Sažetak
Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrant extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the propensity to discriminate between the formulations.
The t50 and t80 values were indicative of the fact that drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.

Ključne riječi
efaverinz; superdisintegrants; granulation

Hrčak ID: 52251

URI
https://hrcak.srce.hr/52251

[hrvatski]

Posjeta: 1.367 *