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Acta Pharmaceutica, Vol. 60 No. 3, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0024-9

Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity

ZRINKA RAJIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
MARIJANA ZOVKO KONČIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
KRISTINA MILOLOŽA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
IVANA PERKOVIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
IVAN BUTULA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
FRANZ BUCAR ; Institut für Pharmazeutische Wissenschaften, Bereich Pharmakognosie, Graz, Austria
BRANKA ZORC ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (198 KB) str. 325-337 preuzimanja: 866* citiraj
APA 6th Edition
RAJIĆ, Z., ZOVKO KONČIĆ, M., MILOLOŽA, K., PERKOVIĆ, I., BUTULA, I., BUCAR, F. i ZORC, B. (2010). Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity. Acta Pharmaceutica, 60 (3), 325-337. https://doi.org/10.2478/v10007-010-0024-9
MLA 8th Edition
RAJIĆ, ZRINKA, et al. "Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity." Acta Pharmaceutica, vol. 60, br. 3, 2010, str. 325-337. https://doi.org/10.2478/v10007-010-0024-9. Citirano 23.02.2019.
Chicago 17th Edition
RAJIĆ, ZRINKA, MARIJANA ZOVKO KONČIĆ, KRISTINA MILOLOŽA, IVANA PERKOVIĆ, IVAN BUTULA, FRANZ BUCAR i BRANKA ZORC. "Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity." Acta Pharmaceutica 60, br. 3 (2010): 325-337. https://doi.org/10.2478/v10007-010-0024-9
Harvard
RAJIĆ, Z., et al. (2010). 'Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity', Acta Pharmaceutica, 60(3), str. 325-337. doi: https://doi.org/10.2478/v10007-010-0024-9
Vancouver
RAJIĆ Z, ZOVKO KONČIĆ M, MILOLOŽA K, PERKOVIĆ I, BUTULA I, BUCAR F i sur. Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity. Acta Pharm. [Internet]. 2010 [pristupljeno 23.02.2019.];60(3):325-337. doi: https://doi.org/10.2478/v10007-010-0024-9
IEEE
Z. RAJIĆ, et al., "Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ chelating activity", Acta Pharmaceutica, vol.60, br. 3, str. 325-337, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0024-9

Sažetak
Novel primaquine conjugates with non-steroidal anti-inflammatory drugs (PQ-NSAIDs, 4a-h) were prepared, fully chemically characterized and screened for radical scavenging and antioxidant activities. The synthetic procedure leading to twin drugs 4a-h involved two steps: i) preparation of NSAID benzotriazolides 3a-h from the corresponding NSAID (ibuprofen, ketoprofen, fenoprofen, ketoprofen hydroxy and methylene analogues, diclofenac or indomethacin) and benzotriazole carboxylic acid chloride (BtCOCl, 1), ii) reaction of intermediates 3a-h with PQ. The prepared PQ-NSAIDs exerted moderate activities in the DPPH free radical test and -carotene-linoleic acid assay. Moreover, ketoprofen derivatives 4d and 4b demonstrated a notable Fe2+ chelating ability as well. On the other hand, negligible antiproliferative and antituberculotic effects of conjugates 4a-h were observed.

Ključne riječi
primaquine; NSAID; twin drug; conjugate; radical scavenging; antioxidant activity; chelating ability

Hrčak ID: 53494

URI
https://hrcak.srce.hr/53494

[hrvatski]

Posjeta: 1.203 *