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Acta Pharmaceutica, Vol. 60 No. 3, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0026-7

Priprava, in vitro i in vivo evaluacija bioadhezivnih mikrosfera s algino-pektinom: ispitivanje utjecaja polimera pomoću multiple poredbene analize

SANTANU CHAKRABORTY ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
MADHUSMRUTI KHANDAI ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
ANURADHA SHARMA ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
NAZIA KHANAM ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
CH. NIRANJAN PATRA ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
V. JAGANNATH PATRO ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
KALYAN KUMAR SEN ; Department of Pharmaceutics, College of Technological Sciences, West Bengal, India

Puni tekst: engleski, pdf (202 KB) str. 255-266 preuzimanja: 550* citiraj
APA 6th Edition
CHAKRABORTY, S., KHANDAI, M., SHARMA, A., KHANAM, N., PATRA, C.N., PATRO, V.J. i KUMAR SEN, K. (2010). Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis. Acta Pharmaceutica, 60 (3), 255-266. https://doi.org/10.2478/v10007-010-0026-7
MLA 8th Edition
CHAKRABORTY, SANTANU, et al. "Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis." Acta Pharmaceutica, vol. 60, br. 3, 2010, str. 255-266. https://doi.org/10.2478/v10007-010-0026-7. Citirano 21.02.2019.
Chicago 17th Edition
CHAKRABORTY, SANTANU, MADHUSMRUTI KHANDAI, ANURADHA SHARMA, NAZIA KHANAM, CH. NIRANJAN PATRA, V. JAGANNATH PATRO i KALYAN KUMAR SEN. "Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis." Acta Pharmaceutica 60, br. 3 (2010): 255-266. https://doi.org/10.2478/v10007-010-0026-7
Harvard
CHAKRABORTY, S., et al. (2010). 'Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis', Acta Pharmaceutica, 60(3), str. 255-266. doi: https://doi.org/10.2478/v10007-010-0026-7
Vancouver
CHAKRABORTY S, KHANDAI M, SHARMA A, KHANAM N, PATRA CN, PATRO VJ i sur. Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis. Acta Pharm. [Internet]. 2010 [pristupljeno 21.02.2019.];60(3):255-266. doi: https://doi.org/10.2478/v10007-010-0026-7
IEEE
S. CHAKRABORTY, et al., "Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis", Acta Pharmaceutica, vol.60, br. 3, str. 255-266, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0026-7

Sažetak
U radu je opisana priprava algino-pektinskih bioadhezivnih mikrosfera protuupalnog lijeka aceklofenaka metodom ionotropnog geliranja. In vitro je ispitivana mogućnost postupnog oslobađanja ljekovite tvari iz mikrosfera te mogućnost upotrebe mikrosfera kao gastroprotektivnog sustava za isporuku aceklofenaka in vivo. Ispitivan je utjecaj koncentracije polimera i omjera polimera i lijeka na svojstva mikrosfera. Mikrosfere su bile bioahezivne i sadržavale su veliki udio lijeka. Oslobađanje aceklofenaka iz alginatnih mikrosfera bilo je brže, a iz mikrosfera s algino-pektinom usporeno. Dunnetova multipla analiza ukazuje na značajnu razliku u postotku inhibicije edema šape kada se usporede optimizirana formulacija i čista ljekovita tvar. Može se zaključiti da su bioadhezivne mikrosfere s algino-pektinom povoljne za usporeno oslobađanje aceklofenaka te da pružaju umjerenu zaštitu sluznice želuca.

Ključne riječi
mikrosfere s algino-pektinom; aceklofenak; bioadhezija; ionotropno geliranje; ispitivanje in vivo

Hrčak ID: 53496

URI
https://hrcak.srce.hr/53496

[engleski]

Posjeta: 823 *