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Acta Pharmaceutica, Vol. 60 No. 3, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0029-4

Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers

DIVYESH H. SHASTRI   ORCID icon orcid.org/0000-0002-0968-0749 ; Department of Pharmaceutics, K. B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat-382023, India
SHAILESH T. PRAJAPATI ; Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana, India -384001
LAXMANBHAI D. PATEL ; Director & Professor, C. U. Shah College of Pharmacy & Research, Wadhwan, Gujarat-363030, India

Puni tekst: engleski, pdf (224 KB) str. 349-360 preuzimanja: 907* citiraj
APA 6th Edition
SHASTRI, D.H., PRAJAPATI, S.T. i PATEL, L.D. (2010). Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers. Acta Pharmaceutica, 60 (3), 349-360. https://doi.org/10.2478/v10007-010-0029-4
MLA 8th Edition
SHASTRI, DIVYESH H., et al. "Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers." Acta Pharmaceutica, vol. 60, br. 3, 2010, str. 349-360. https://doi.org/10.2478/v10007-010-0029-4. Citirano 20.02.2019.
Chicago 17th Edition
SHASTRI, DIVYESH H., SHAILESH T. PRAJAPATI i LAXMANBHAI D. PATEL. "Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers." Acta Pharmaceutica 60, br. 3 (2010): 349-360. https://doi.org/10.2478/v10007-010-0029-4
Harvard
SHASTRI, D.H., PRAJAPATI, S.T., i PATEL, L.D. (2010). 'Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers', Acta Pharmaceutica, 60(3), str. 349-360. doi: https://doi.org/10.2478/v10007-010-0029-4
Vancouver
SHASTRI DH, PRAJAPATI ST, PATEL LD. Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers. Acta Pharm. [Internet]. 2010 [pristupljeno 20.02.2019.];60(3):349-360. doi: https://doi.org/10.2478/v10007-010-0029-4
IEEE
D.H. SHASTRI, S.T. PRAJAPATI i L.D. PATEL, "Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers", Acta Pharmaceutica, vol.60, br. 3, str. 349-360, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0029-4

Sažetak
The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 3336 ºC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.

Ključne riječi
moxifloxacin hydrochloride; in situ gel; ophthalmic drug delivery; mucoadhesive polymers; 32 full factorial design

Hrčak ID: 53499

URI
https://hrcak.srce.hr/53499

[hrvatski]

Posjeta: 1.119 *