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Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]

Lea Kukoc-Modun   ORCID icon orcid.org/0000-0003-1798-6796 ; Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21000 Split, Croatia
Njegomir Radić ; Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21000 Split, Croatia

Puni tekst: engleski, pdf (3 MB) str. 189-195 preuzimanja: 741* citiraj
APA 6th Edition
Kukoc-Modun, L. i Radić, Nj. (2010). Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]. Croatica Chemica Acta, 83 (2), 189-195. Preuzeto s https://hrcak.srce.hr/56022
MLA 8th Edition
Kukoc-Modun, Lea i Njegomir Radić. "Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]." Croatica Chemica Acta, vol. 83, br. 2, 2010, str. 189-195. https://hrcak.srce.hr/56022. Citirano 22.09.2019.
Chicago 17th Edition
Kukoc-Modun, Lea i Njegomir Radić. "Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]." Croatica Chemica Acta 83, br. 2 (2010): 189-195. https://hrcak.srce.hr/56022
Harvard
Kukoc-Modun, L., i Radić, Nj. (2010). 'Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]', Croatica Chemica Acta, 83(2), str. 189-195. Preuzeto s: https://hrcak.srce.hr/56022 (Datum pristupa: 22.09.2019.)
Vancouver
Kukoc-Modun L, Radić Nj. Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]. Croatica Chemica Acta [Internet]. 2010 [pristupljeno 22.09.2019.];83(2):189-195. Dostupno na: https://hrcak.srce.hr/56022
IEEE
L. Kukoc-Modun i Nj. Radić, "Novel Kinetic Spectrophotometric Method for Determination of Tiopronin [N-(2-Mercaptopropionyl)-glycine]", Croatica Chemica Acta, vol.83, br. 2, str. 189-195, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/56022. [Citirano: 22.09.2019.]

Sažetak
Novel simple kinetic spectrophotometric method for the determination of tiopronin [N-(2-mercaptopropionyl)-glycine, MPG] in pharmaceutical formulation has been developed and validated. The
proposed method is based on the coupled redox-complexation reaction whose first step is reduction of
FeIII by MPG, while second one includes the complexation of FeII, resulted from preceding redox reaction,
with 2,4,6-trypyridyl-s-triazine (TPTZ). The stable Fe(TPTZ)22+ complex exhibits an absorption maximum
at  = 593 nm. The initial rate and fixed time (at 3 min) methods were utilized for constructing the calibration graphs.
The graphs were linear in concentration ranges from 1.0  10−6 to 1.0  10−4 mol L−1 for both methods with
limits of detection 1.3  10−7 mol L−1 and 7.5  10−8 mol L−1 for the initial rate and fixed time method, respectively.
The proposed methods were successfully applied for the determination of MPG in its commercial
pharmaceutical formulation.

Ključne riječi
tiopronin; N-(2-mercaptopropionyl)-glycine; kinetic spectrophotometry; initial rate method; fixed time method; pharmaceutical analysis

Hrčak ID: 56022

URI
https://hrcak.srce.hr/56022

Posjeta: 963 *