Acta clinica Croatica, Vol. 49 No. 1, 2010.
Izvorni znanstveni članak
Electrophysiological Effects, Efficacy and Safety of Intravenous Propafenone in Termination of Atrioventricular Nodal Reentrant Tachycardia and Atrioventricular Reentrant Tachycardia: A Prospective Non-Randomized Interventional Study
Hrvoje Pintarić
Šime Manola
Janko Szavits Nossan
Nikola Pavlović
Diana Delić-Brkljačić
Vjekoslav Radeljić
Sažetak
The aim of this prospective, non-randomized interventional study was to assess electrophysiological effects, efficacy and safety of intravenous propafenone in termination of atrioventricular nodal reentrant tachycardia (AVNRT) and orthodromic atrioventricular reentrant tachycardia (AVRT). This single-center study was carried out at Department of Cardiology, Sestre milosrdnice University Hospital in Zagreb, Croatia, between January 1, 2005 and December 31, 2006. Eligibility requirements were fulfilled by a total of 70 patients with AVNRT (n=37) and AVRT (n=33). The intervention consisted of the electrophysiological study aimed at inducing tachycardia, followed by intravenous administration of 2 mg/kg propafenone in both groups. The main outcome measures were safety and efficacy of 2 mg/kg intravenous propafenone in tachycardia termination and re-induction. Out of 37 patients with AVNRT, propafenone managed to terminate it in 28 (75.7%) patients, while tachycardia was not inducible in 25 (67.56%) patients. Out of 33patients with AVRT, propafenone managed to terminate AVRT in 29 (87.9%) patients, while tachycardia was not inducible in 22 (66.66%) patients. The overall propafenone efficacy in tachycardia termination was 81.42%. No propafenone-related adverse effects were recorded during the study period. Propafenone was found to be a safe and effective anti-arrhythmic drug and can be justifiably administered for AVNRT and AVRT termination. It could be considered as an alternative to adenosine and verapamil.
Ključne riječi
Anti-arrhythmia agents – therapeutic use; Propafenone – therapeutic use; Tachycardia, supraventricular – drug therapy; Electrophysiologic techniques, cardiac
Hrčak ID:
56803
URI
Datum izdavanja:
1.3.2010.
Posjeta: 1.646 *