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Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0034-7

Formulation and in vitro characterization of spray-dried microspheres of amoxycillin

JIGNYASHA A. RAVAL ; S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway, Kherva-382 711, Gujarat, India
JAYVADAN K. PATEL ; Nootan College of Pharmacy, Gujarat Technical University, Visnagar-384315, Gujarat, India
MADHABHAI M. PATEL ; Kalol Institute of Pharmacy, Gujarat Technical University, B/h Old Janpath Hotel, National Highway, Kalol-382721, Gujarat, India

Puni tekst: engleski, pdf (151 KB) str. 455-465 preuzimanja: 818* citiraj
APA 6th Edition
RAVAL, J.A., PATEL, J.K. i PATEL, M.M. (2010). Formulation and in vitro characterization of spray-dried microspheres of amoxycillin. Acta Pharmaceutica, 60 (4), 455-465. https://doi.org/10.2478/v10007-010-0034-7
MLA 8th Edition
RAVAL, JIGNYASHA A., et al. "Formulation and in vitro characterization of spray-dried microspheres of amoxycillin." Acta Pharmaceutica, vol. 60, br. 4, 2010, str. 455-465. https://doi.org/10.2478/v10007-010-0034-7. Citirano 24.08.2019.
Chicago 17th Edition
RAVAL, JIGNYASHA A., JAYVADAN K. PATEL i MADHABHAI M. PATEL. "Formulation and in vitro characterization of spray-dried microspheres of amoxycillin." Acta Pharmaceutica 60, br. 4 (2010): 455-465. https://doi.org/10.2478/v10007-010-0034-7
Harvard
RAVAL, J.A., PATEL, J.K., i PATEL, M.M. (2010). 'Formulation and in vitro characterization of spray-dried microspheres of amoxycillin', Acta Pharmaceutica, 60(4), str. 455-465. https://doi.org/10.2478/v10007-010-0034-7
Vancouver
RAVAL JA, PATEL JK, PATEL MM. Formulation and in vitro characterization of spray-dried microspheres of amoxycillin. Acta Pharm. [Internet]. 2010 [pristupljeno 24.08.2019.];60(4):455-465. https://doi.org/10.2478/v10007-010-0034-7
IEEE
J.A. RAVAL, J.K. PATEL i M.M. PATEL, "Formulation and in vitro characterization of spray-dried microspheres of amoxycillin", Acta Pharmaceutica, vol.60, br. 4, str. 455-465, 2010. [Online]. https://doi.org/10.2478/v10007-010-0034-7

Sažetak
The purpose of the present study was to design mucoadhesive chitosan microspheres containing amoxycillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the extent of crosslinking were the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and in vitro drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres.

Ključne riječi
amoxycillin; prolonged/sustained release; chitosan; spray dried microspheres

Hrčak ID: 59302

URI
https://hrcak.srce.hr/59302

[hrvatski]

Posjeta: 1.007 *