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Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period

Smiljka Popović Suić
Katia Novak Lauš
Vukosava Maričič Došen
Miroslav Ekert
Zdravko Mandić
Lovro Bojić

Puni tekst: engleski, pdf (107 KB) str. 847-852 preuzimanja: 256* citiraj
APA 6th Edition
Popović Suić, S., Novak Lauš, K., Maričič Došen, V., Ekert, M., Mandić, Z. i Bojić, L. (2010). Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period. Collegium antropologicum, 34 (3), 847-852. Preuzeto s https://hrcak.srce.hr/59316
MLA 8th Edition
Popović Suić, Smiljka, et al. "Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period." Collegium antropologicum, vol. 34, br. 3, 2010, str. 847-852. https://hrcak.srce.hr/59316. Citirano 14.06.2021.
Chicago 17th Edition
Popović Suić, Smiljka, Katia Novak Lauš, Vukosava Maričič Došen, Miroslav Ekert, Zdravko Mandić i Lovro Bojić. "Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period." Collegium antropologicum 34, br. 3 (2010): 847-852. https://hrcak.srce.hr/59316
Harvard
Popović Suić, S., et al. (2010). 'Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period', Collegium antropologicum, 34(3), str. 847-852. Preuzeto s: https://hrcak.srce.hr/59316 (Datum pristupa: 14.06.2021.)
Vancouver
Popović Suić S, Novak Lauš K, Maričič Došen V, Ekert M, Mandić Z, Bojić L. Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period. Collegium antropologicum [Internet]. 2010 [pristupljeno 14.06.2021.];34(3):847-852. Dostupno na: https://hrcak.srce.hr/59316
IEEE
S. Popović Suić, K. Novak Lauš, V. Maričič Došen, M. Ekert, Z. Mandić i L. Bojić, "Comparison of Evening and Morning Dosing of Travoprost 0.004%/Timolol 0.5% Fixed Combination in 6 Month Period", Collegium antropologicum, vol.34, br. 3, str. 847-852, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/59316. [Citirano: 14.06.2021.]

Sažetak
An open label, multi-center, 6 months observational study of new fixed combination (travoprost 0.004%/timolol 0.5%), in order to evaluate both efficacy (intraocular pressure lowering) and tolerability (patient and investigator satisfaction) of two dosing regimens –evening (PM) and morning (AM). After scrrening for enrollment, to 40 patients (79 eyes with primary open angle glaucoma or ocular hypertension), new fixed combination travoprost 0.004%/timolol 0.5% was prescribed once a day in the evening (PM). Patients were enrolled according to each investigator decision on indication for travoprost 0.004%/timolol 0.5% fixed combination once a day, without washout period after previous medication. Intraocular pressure was measured at 9 AM at all time control points: at baseline, after 1 month, after 3 months and after 6 month. After 1 month, screening for nonresponders (criteria: 20% intraocular pressure lowering) and subjects with major side effects was performed. At second control visit, after 3 months PM dosing, intraocular pressure was measured and patients were instructed to continue once a day the same medication, but in the morning (AM) for consequent 3 months. After 1 month, reduction in mean intraocular pressure value was 21.66%. At the visit after 3 month, the mean intraocular pressure was 15.67±2.17 mm Hg (reduction 21.14%). 3 month after dosing regimen changed to AM (6 month after beginning of travoprost 0.004%/timolol 0.5% combination therapy), reduction in intraocular pressure value was 19.86%. The differences (mean±standard deviation) in intraocular pressure values after 1, 3 nad 6 month were all highly statistically significant compared to baseline values. The tolerability was evaluated in five steps (Likert scale) ranging from unsatisfactory to excellent by both patient and investigator – taken at 3 and 6 month control visit. 95% of patients and 100% of investigators were satisfied with the possibility of choosing dosing regimen for travoprost 0.004%/timolol 0.5% fixed combination. Travoprost 0.004%/timolol 0.5% fixed combination proved sufficient intraocular pressure control dosed either PM or AM with no statistically significant difference between two dosing regimens. Possibility to choose between two dosing regimens gives each practitioner additional reassurance that glaucoma therapy will be individualised to needs of each patient.

Ključne riječi
travoprost 0.004%/timolol 0.5%; glaucoma; dosing regimen

Hrčak ID: 59316

URI
https://hrcak.srce.hr/59316

Posjeta: 511 *