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Preliminary communication

Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery

Mladen Carev
Cristijan Bulat
Nenad Karanović
Mihajlo Lojpur
Antonio Jerčić
Denis Nenadić
Zlatko Marović
Ino Husedžinović
Dalibor Letica

Fulltext: english, pdf (65 KB) pages 1113-1117 downloads: 427* cite
APA 6th Edition
Carev, M., Bulat, C., Karanović, N., Lojpur, M., Jerčić, A., Nenadić, D., ... Letica, D. (2010). Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery. Collegium antropologicum, 34 (3), 1113-1117. Retrieved from https://hrcak.srce.hr/59391
MLA 8th Edition
Carev, Mladen, et al. "Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery." Collegium antropologicum, vol. 34, no. 3, 2010, pp. 1113-1117. https://hrcak.srce.hr/59391. Accessed 23 Sep. 2021.
Chicago 17th Edition
Carev, Mladen, Cristijan Bulat, Nenad Karanović, Mihajlo Lojpur, Antonio Jerčić, Denis Nenadić, Zlatko Marović, Ino Husedžinović and Dalibor Letica. "Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery." Collegium antropologicum 34, no. 3 (2010): 1113-1117. https://hrcak.srce.hr/59391
Harvard
Carev, M., et al. (2010). 'Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery', Collegium antropologicum, 34(3), pp. 1113-1117. Available at: https://hrcak.srce.hr/59391 (Accessed 23 September 2021)
Vancouver
Carev M, Bulat C, Karanović N, Lojpur M, Jerčić A, Nenadić D, et al. Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery. Collegium antropologicum [Internet]. 2010 [cited 2021 September 23];34(3):1113-1117. Available from: https://hrcak.srce.hr/59391
IEEE
M. Carev, et al., "Combined Usage of Inhaled and Intravenous Milrinone in Pulmonary Hypertension after Heart Valve Surgery", Collegium antropologicum, vol.34, no. 3, pp. 1113-1117, 2010. [Online]. Available: https://hrcak.srce.hr/59391. [Accessed: 23 September 2021]

Abstracts
Secondary pulmonary hypertension is a frequent condition after heart valve surgery. It may significantly complicate the perioperative management and increase patients’ morbidity and mortality. The treatment has not been yet completely defined principally because of lack of the selectivity of drugs for the pulmonary vasculature. The usage of inhaled milrinone could be the possible therapeutic option. Inodilator milrinone is commonly used intravenously for patients with pulmonary hypertension and ventricular dysfunction in cardiac surgery. The decrease in systemic vascular resistance frequently necessitates concomitant use of norepinephrine. Pulmonary vasodilators might be more effective and also devoid of potentially dangerous systemic side effects if applied by inhalation, thus acting predominantly on pulmonary circulation. There are only few reports of inhaled milrinone usage in adult post cardiac surgical patients. We reported 2 patients with severe pulmonary hypertension after valve surgery. Because of desperate clinical situation, we decided to use the combination of inhaled and intravenous milrinone. Inhaled milrinone was delivered by means of pneumatic medication nebulizer dissolved with saline in final concentration of 0.5 mg/ml. The nebulizer was attached to the inspiratory limb of the ventilator circuit, just before the Y-piece. We obtained satisfactory reduction in mean pulmonary artery pressure in both patients, and they were successfully extubated and discharged. Although it is a very small sample of patients, we conclude that the combination of inhaled and intravenous milrinone could be an effective treatment of secondary pulmonary hypertension in high-risk cardiac valve surgery patient. The exact indications for inhaled milrinone usage, optimal concentrations for this route, and the beginning and duration of treatment are yet to be determined.

Keywords
milrinone; heart surgery; aerosol drug therapy; nebulizers; pulmonary hypertension

Hrčak ID: 59391

URI
https://hrcak.srce.hr/59391

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