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Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0038-3

Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution

DALWADI SONALI ; Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa-388421, India
SONI TEJAL ; Anand Pharmacy College, Anand-388001, India
THAKKAR VAISHALI ; Anand Pharmacy College, Anand-388001, India
GANDHI TEJAL ; Anand Pharmacy College, Anand-388001, India

Puni tekst: engleski, pdf (433 KB) str. 427-443 preuzimanja: 994* citiraj
APA 6th Edition
SONALI, D., TEJAL, S., VAISHALI, T. i TEJAL, G. (2010). Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution. Acta Pharmaceutica, 60 (4), 427-443. https://doi.org/10.2478/v10007-010-0038-3
MLA 8th Edition
SONALI, DALWADI, et al. "Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution." Acta Pharmaceutica, vol. 60, br. 4, 2010, str. 427-443. https://doi.org/10.2478/v10007-010-0038-3. Citirano 24.08.2019.
Chicago 17th Edition
SONALI, DALWADI, SONI TEJAL, THAKKAR VAISHALI i GANDHI TEJAL. "Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution." Acta Pharmaceutica 60, br. 4 (2010): 427-443. https://doi.org/10.2478/v10007-010-0038-3
Harvard
SONALI, D., et al. (2010). 'Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution', Acta Pharmaceutica, 60(4), str. 427-443. https://doi.org/10.2478/v10007-010-0038-3
Vancouver
SONALI D, TEJAL S, VAISHALI T, TEJAL G. Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution. Acta Pharm. [Internet]. 2010 [pristupljeno 24.08.2019.];60(4):427-443. https://doi.org/10.2478/v10007-010-0038-3
IEEE
D. SONALI, S. TEJAL, T. VAISHALI i G. TEJAL, "Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution", Acta Pharmaceutica, vol.60, br. 4, str. 427-443, 2010. [Online]. https://doi.org/10.2478/v10007-010-0038-3

Sažetak
The influence of preparation methodology of silymarin solid dispersions using a hydrophilic polymer on the dissolution performance of silymarin was investigated. Silymarin solid dispersions were prepared using HPMC E 15LV by kneading, spray drying and co-precipitation methods and characterized by FTIR, DSC, XRPD and SEM. Dissolution profiles were compared by statistical and model independent methods. The FTIR and DSC studies revealed weak hydrogen bond formation between the drug and polymer, while XRPD and SEM confirmed the amorphous nature of the drug in co-precipitated solid dispersion. Enhanced dissolution compared to pure drug was found in the following order: co-precipitation > spray drying > kneading methodology (p < 0.05). All preparation methods enhanced silymarin dissolution from solid dispersions of different characteristics. The co-precipitation method proved to be best and provided a stable amorphous solid dispersion with 2.5 fold improved dissolution compared to the pure drug.

Ključne riječi
silymarin; HPMC; solid dispersions; kneading; spray drying; co-precipitation; dissolution parameters

Hrčak ID: 59807

URI
https://hrcak.srce.hr/59807

[hrvatski]

Posjeta: 1.319 *