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Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV

Lukasz Guzik ; Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Hallera 107 80-416 Gdansk, Poland
Wojciech Mrozik ; Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Hallera 107 80-416 Gdansk, Poland
Wojciech Kamysz ; Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Hallera 107 80-416 Gdansk, Poland

Puni tekst: engleski, pdf (2 MB) str. 371-377 preuzimanja: 4.920* citiraj
APA 6th Edition
Guzik, L., Mrozik, W. i Kamysz, W. (2010). Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV. Croatica Chemica Acta, 83 (4), 371-377. Preuzeto s https://hrcak.srce.hr/62222
MLA 8th Edition
Guzik, Lukasz, et al. "Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV." Croatica Chemica Acta, vol. 83, br. 4, 2010, str. 371-377. https://hrcak.srce.hr/62222. Citirano 25.02.2021.
Chicago 17th Edition
Guzik, Lukasz, Wojciech Mrozik i Wojciech Kamysz. "Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV." Croatica Chemica Acta 83, br. 4 (2010): 371-377. https://hrcak.srce.hr/62222
Harvard
Guzik, L., Mrozik, W., i Kamysz, W. (2010). 'Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV', Croatica Chemica Acta, 83(4), str. 371-377. Preuzeto s: https://hrcak.srce.hr/62222 (Datum pristupa: 25.02.2021.)
Vancouver
Guzik L, Mrozik W, Kamysz W. Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV. Croatica Chemica Acta [Internet]. 2010 [pristupljeno 25.02.2021.];83(4):371-377. Dostupno na: https://hrcak.srce.hr/62222
IEEE
L. Guzik, W. Mrozik i W. Kamysz, "Determination of Simvastatin in Pharmaceutical Dosage Forms by Optimized and Validated Method Using HPLC/UV", Croatica Chemica Acta, vol.83, br. 4, str. 371-377, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/62222. [Citirano: 25.02.2021.]

Sažetak
Simvastatin belongs to the group of anticholesterol agents used in the treatment of hypercholesteraemia.
Analytical methods used to determine the concentration of this active pharmaceutical ingredient
(API), in dosage forms in the quality tests, are commonly based on high performance liquid chromatography
(HPLC) and should be fast and reliable. The purpose of this study was to compare and validate two
methods of analysis of simvastatin using HPLC and different eluent mixtures: acetonitrile/water vs. methanol/
water in gradient elution. Several columns were tested at different temperatures. However satisfied
peak shapes and validation parameters were obtained for both methods. The one using methanol as an eluent
was chosen for the determination of simvastatin in dissolution tests, mostly due to lower price of the eluent.

Ključne riječi
simvastatin; HPLC/UV; gradient elution; methanol/water; dissolution tests

Hrčak ID: 62222

URI
https://hrcak.srce.hr/62222

Posjeta: 5.425 *