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Acta Pharmaceutica, Vol. 61 No. 1, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0002-x

Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”

AMIT KUMAR NAYAK ; Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol-713301, India
BIBEK LAHA ; Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol-713301, India
KALYAN KUMAR SEN

Puni tekst: engleski, pdf (153 KB) str. 25-36 preuzimanja: 636* citiraj
APA 6th Edition
NAYAK, A.K., LAHA, B. i SEN, K.K. (2011). Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”. Acta Pharmaceutica, 61 (1), 25-36. https://doi.org/10.2478/v10007-011-0002-x
MLA 8th Edition
NAYAK, AMIT KUMAR, et al. "Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 25-36. https://doi.org/10.2478/v10007-011-0002-x. Citirano 25.05.2019.
Chicago 17th Edition
NAYAK, AMIT KUMAR, BIBEK LAHA i KALYAN KUMAR SEN. "Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”." Acta Pharmaceutica 61, br. 1 (2011): 25-36. https://doi.org/10.2478/v10007-011-0002-x
Harvard
NAYAK, A.K., LAHA, B., i SEN, K.K. (2011). 'Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”', Acta Pharmaceutica, 61(1), str. 25-36. doi: https://doi.org/10.2478/v10007-011-0002-x
Vancouver
NAYAK AK, LAHA B, SEN KK. Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”. Acta Pharm. [Internet]. 2011 [pristupljeno 25.05.2019.];61(1):25-36. doi: https://doi.org/10.2478/v10007-011-0002-x
IEEE
A.K. NAYAK, B. LAHA i K.K. SEN, "Development of hydroxyapatite-ciprofloxacin bone-implants using “Quality by design”", Acta Pharmaceutica, vol.61, br. 1, str. 25-36, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0002-x

Sažetak
The present study deals with the development of hydroxyapatite (HAp)-ciprofloxacin bone-
-implants using the “Quality by design” approach. The effect of various synthetic parameters like drug amount added in the process, stirring speed and addition rate of orthophosphoric acid on drug concentration in the HAp-ciprofloxacin system synthesized by the precipitation technique using 23 factorial design was analyzed. Optimization methodology utilizing the first-order polynomial equation was used to search for optimal drug concentration in the HAp-ciprofloxacin implant system. The observed responses coincided well with the predicted values from the optimization technique. New implants were manufactured using various HAp-ciprofloxacin composites and 1.5 % (m/V) guar gum as a binder. Characterization of the delivery system was done by XRPD, FTIR spectroscopy and SEM. Even at highest drug concentration (76.6 ± 0.5 %, m/m), ciprofloxacin was present in noncrystalline state. The in vitro ciprofloxacin release from various bone-implants was sustained for several weeks and the drug release pattern correlated well with the Korsmeyer-Peppas model.

Ključne riječi
hydroxyapatite; ciprofloxacin; bone-implant; “Quality by design”; osteomyelitis

Hrčak ID: 63375

URI
https://hrcak.srce.hr/63375

[hrvatski]

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